Articles liés à OPTIMIZATION TECHNIQUE: POLYMERIC FILMS WITH COMPARABLE...

OPTIMIZATION TECHNIQUE: POLYMERIC FILMS WITH COMPARABLE PERMEATION TO ANIMALS SKIN - Couverture souple

RANA, VIKAS; K TIWARY, ASHOK

 
9783838381114: OPTIMIZATION TECHNIQUE: POLYMERIC FILMS WITH COMPARABLE PERMEATION TO ANIMALS SKIN
Couverture souple
ISBN 10 : 3838381114 ISBN 13 : 9783838381114
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

The present investigation was designed with an aim to formulate Chitosan (CH) films by cross-linking with Sodium citrate (Nacit), Sodium tripolyphosphate (NaTPP) or Chondroitin sulphate (CS) that shall be capable of simulating the in vitro permeation of model polar drug, 5-Fluorouracil (5-FU) and non polar drug, Indomethacin (INDO) across rat/rabbit or human epidermis. Optimization design was employed to identify and optimize various process and formulation variables significantly (p<0.05) influencing permeation of both drugs across these films. Further, the results were evaluated for the effect of cross linking density on in vitro permeation using atomic absorption spectroscopic analysis for Na+, DSC and IR spectroscopic analysis. The in vitro permeation of both 5-FU and INDO across optimized film formulations of films crosslinked with CH-NaTPP, CH-Nacit or CH-CS was found to be comparable to that obtained across rat, rabbit and human epidermal sheets. These results indicate that these optimized CH films have a potential to be developed as substitute for animal and human cadaver epidermal sheets for preliminary in vitro permeation studies

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The present investigation was designed with an aim to formulate Chitosan (CH) films by cross-linking with Sodium citrate (Nacit), Sodium tripolyphosphate (NaTPP) or Chondroitin sulphate (CS) that shall be capable of simulating the in vitro permeation of model polar drug, 5-Fluorouracil (5-FU) and non polar drug, Indomethacin (INDO) across rat/rabbit or human epidermis. Optimization design was employed to identify and optimize various process and formulation variables significantly (p<0.05) influencing permeation of both drugs across these films. Further, the results were evaluated for the effect of cross linking density on in vitro permeation using atomic absorption spectroscopic analysis for Na+, DSC and IR spectroscopic analysis. The in vitro permeation of both 5-FU and INDO across optimized film formulations of films crosslinked with CH-NaTPP, CH-Nacit or CH-CS was found to be comparable to that obtained across rat, rabbit and human epidermal sheets. These results indicate that these optimized CH films have a potential to be developed as substitute for animal and human cadaver epidermal sheets for preliminary in vitro permeation studies

Biographie de l'auteur

Dr. Vikas Rana, born on Feb, 1971, has published more than 30 research papers and associated with the projects funded by DST, UGC and AICTE, New Delhi. His present thrust areas of research are Formulation development and evaluation of orally disintegrating tablets and Colo-rectal drug delivery systems using a natural polymers.

Dr. Vikas Rana, born on Feb, 1971, has published more than 30 research papers and associated with the projects funded by DST, UGC and AICTE, New Delhi. His present thrust areas of research are Formulation development and evaluation of orally disintegrating tablets and Colo-rectal drug delivery systems using a natural polymers.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3838381114
ISBN 13 
9783838381114
Reliure
Broché
Nombre de pages
204
Coordonnées du fabricant
non disponible
Personne responsable
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