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Lysophosphatidic Acid Induction Of Tissue Factor Gene Expression: A Molecular Study In Vascular Smooth Muscle Cells - Couverture souple

Laag, Essam

 
9783838381374: Lysophosphatidic Acid Induction Of Tissue Factor Gene Expression: A Molecular Study In Vascular Smooth Muscle Cells
Couverture souple
ISBN 10 : 3838381378 ISBN 13 : 9783838381374
Editeur : LAP LAMBERT Academic Publishing, 2010

Synopsis

LPA is a component of oxidized low density lipoproteins (oxLDL) which has been shown to accumulate in human atherosclerotic plaques. Tissue factor (TF) is the principal initiator of blood coagulation. Tissue factor upregulation in atherosclerotic plaque can lead to undesirable vascular thrombosis. The generation of reactive oxygen species (ROS), which act as signaling molecules in the vascular system, is enhanced in response to injury and has been associated with a procoagulant state and the progression of atherosclerotic disease. Oxidative stress might contribute to the increased expression of pro atherosclerotic genes at sites of vascular injury, including TF. Little is known about the regulation of TF by LPA in smooth muscle cells (SMC) which is a major player in the process of atherosclerosis. Data generated by this study demonstrate that LPA markedly induces TF expression in rat aorta smooth muscle cells (RASMCs) and human aorta smooth muscle cells (HASMCs). The signaling pathways involved are multiple.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

LPA is a component of oxidized low density lipoproteins (oxLDL) which has been shown to accumulate in human atherosclerotic plaques. Tissue factor (TF) is the principal initiator of blood coagulation. Tissue factor upregulation in atherosclerotic plaque can lead to undesirable vascular thrombosis. The generation of reactive oxygen species (ROS), which act as signaling molecules in the vascular system, is enhanced in response to injury and has been associated with a procoagulant state and the progression of atherosclerotic disease. Oxidative stress might contribute to the increased expression of pro atherosclerotic genes at sites of vascular injury, including TF. Little is known about the regulation of TF by LPA in smooth muscle cells (SMC) which is a major player in the process of atherosclerosis. Data generated by this study demonstrate that LPA markedly induces TF expression in rat aorta smooth muscle cells (RASMCs) and human aorta smooth muscle cells (HASMCs). The signaling pathways involved are multiple.

Biographie de l'auteur

Essam Laag was born in Tanta-Egypt in 1962. He graduated from Tanta University Faculty of Medicine, Egypt. He received his Ph.D in comparative and Experimental Medicine at the university of Tennessee in 2000. He is presently a lecturer in the department of Histology at the College of Medicine, University of Tanta, Egypt.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
3838381378
ISBN 13 
9783838381374
Reliure
Broché
Nombre de pages
96
Coordonnées du fabricant
non disponible
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