Articles liés à Autoantibodies in Neurological Disorders: Neuronal...

Autoantibodies in Neurological Disorders: Neuronal and Muscle Autoantibodies in Paraneoplastic Neurological Disorders and Autoimmune Myasthenia Gravis - Couverture souple

CHAN, Koon Ho

 
9783838382203: Autoantibodies in Neurological Disorders: Neuronal and Muscle Autoantibodies in Paraneoplastic Neurological Disorders and Autoimmune Myasthenia Gravis
Couverture souple
ISBN 10 : 383838220X ISBN 13 : 9783838382203
Editeur : LAP LAMBERT Academic Publishing, 2010

Synopsis

Paraneoplastic neurological disorders (PND) are due to immune-mediated damage of the nervous system, and the immune response is believed to be triggered as anti-tumor immunity. Early recognition of PND facilitates prompt detection of underlying tumors. Detection of paraneoplastic neuronal autoantibodies facilitates early diagnosis of PND. A novel paraneoplastic neuronal antibody, anti-neuronal nuclear antibody type 3 (ANNA-3) was identified in eleven patients, the majority had SCLC and diverse neurological manifestations. Autoimmune myasthenia gravis (MG) is due to impaired neuromuscular transmission predominantly due to pathogenic acetylcholine receptor (AChR) autoantibodies. Muscle-specific tyrosine kinase (MuSK) autoantibodies are detected in some AChR autoantibodies-negative generalized MG patients. Among 562 Mayo Clinic patients with adult- onset generalized MG based on clinical and electrophysiological criteria, AChR autoantibodies seronegativity rate was 8.2% and MuSK autoantibodies was detected in 38% of AChR autoantibodies-negative patients. The seronegativity rate in adult-onset generalized MG is ~5%.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Paraneoplastic neurological disorders (PND) are due to immune-mediated damage of the nervous system, and the immune response is believed to be triggered as anti-tumor immunity. Early recognition of PND facilitates prompt detection of underlying tumors. Detection of paraneoplastic neuronal autoantibodies facilitates early diagnosis of PND. A novel paraneoplastic neuronal antibody, anti-neuronal nuclear antibody type 3 (ANNA-3) was identified in eleven patients, the majority had SCLC and diverse neurological manifestations. Autoimmune myasthenia gravis (MG) is due to impaired neuromuscular transmission predominantly due to pathogenic acetylcholine receptor (AChR) autoantibodies. Muscle-specific tyrosine kinase (MuSK) autoantibodies are detected in some AChR autoantibodies-negative generalized MG patients. Among 562 Mayo Clinic patients with adult- onset generalized MG based on clinical and electrophysiological criteria, AChR autoantibodies seronegativity rate was 8.2% and MuSK autoantibodies was detected in 38% of AChR autoantibodies-negative patients. The seronegativity rate in adult-onset generalized MG is ~5%.

Biographie de l'auteur

The author graduated from the Faculty of Medicine, the University of Hong Kong, and started neurology training in the Department of Medicine, University of Hong Kong. He spent one year in 2000-2001 on neuroimmunology research in Mayo CLinic Rochester under the supervision of Professor Vanda A Lennon, a great teacher, scientist and friend.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
383838220X
ISBN 13 
9783838382203
Reliure
Broché
Nombre de pages
256
Coordonnées du fabricant
non disponible
Personne responsable
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