Imatinib plasma concentrations variability in oncologic patients: Is imatinib a candidate drug for a therapeutic drug monitoring program? - Couverture souple

Widmer, Nicolas

 
9783838385112: Imatinib plasma concentrations variability in oncologic patients: Is imatinib a candidate drug for a therapeutic drug monitoring program?
Couverture souple
ISBN 10 : 383838511X ISBN 13 : 9783838385112
Editeur : LAP LAMBERT Academic Publishing, 2010

Synopsis

The anticancer drug imatinib has transformed the treatment and prognosis of chronic myeloid leukemia and gastrointestinal stromal tumor. However, the treatment must be taken indefinitely and is not devoid of inconveniences and toxicity. Moreover, resistance or escape from disease control are occurring. Considering the large interindividual differences in the function of the enzymatic and transport systems involved in imatinib disposition, exposure to this drug can be expected to vary widely among patients. This book describes an observational clinical trial aiming at exploring the influence of these covariates on imatinib pharmacokinetics and assessing the interindividual variability of the pharmacokinetic parameters of the drug. A large interindividual variability was observed, together with some preliminary concentration-effect relationships. These elements are arguments to further investigate the potential benefit of a therapeutic drug monitoring program to optimize the use of imatinib in patients. Such results should be especially useful to clinical oncologists or scientists involved in clinical oncology research.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The anticancer drug imatinib has transformed the treatment and prognosis of chronic myeloid leukemia and gastrointestinal stromal tumor. However, the treatment must be taken indefinitely and is not devoid of inconveniences and toxicity. Moreover, resistance or escape from disease control are occurring. Considering the large interindividual differences in the function of the enzymatic and transport systems involved in imatinib disposition, exposure to this drug can be expected to vary widely among patients. This book describes an observational clinical trial aiming at exploring the influence of these covariates on imatinib pharmacokinetics and assessing the interindividual variability of the pharmacokinetic parameters of the drug. A large interindividual variability was observed, together with some preliminary concentration-effect relationships. These elements are arguments to further investigate the potential benefit of a therapeutic drug monitoring program to optimize the use of imatinib in patients. Such results should be especially useful to clinical oncologists or scientists involved in clinical oncology research.

Biographie de l'auteur

is a Swiss pharmacist who specialized both in Hospital Pharmacy and Clinical Pharmacology, and gained his PhD in Life Sciences in 2006. He is at present in charge of the Therapeutic Drug Monitoring service at the Division of Clinical Pharmacology and Toxicology (University Hospital Center and University of Lausanne).

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
383838511X
ISBN 13 
9783838385112
Reliure
Broché
Nombre de pages
248
Coordonnées du fabricant
non disponible
Personne responsable
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