Mucoadhesive Drug Delivery Systems using Optimized Polymer Blends: Developing Gastroretentive Controlled Release Tablet Formulations of Atenolol using Systematic "Design of Experiments (DoE)" - Couverture souple

Singh, Bhupinder; Kaur, Sukhwinder

 
9783838394251: Mucoadhesive Drug Delivery Systems using Optimized Polymer Blends: Developing Gastroretentive Controlled Release Tablet Formulations of Atenolol using Systematic "Design of Experiments (DoE)"
Couverture souple
ISBN 10 : 3838394259 ISBN 13 : 9783838394251
Editeur : LAP Lambert Academic Publishing, 2010

Synopsis

The work embodies development and systematic optimization of oral controlled release (CR) mucoadhesive hydrophilic matrices of atenolol using "Design of Experiments". A central composite design was used to optimize drug release profile and bioadhesive strength. Two polymers, namely, Carbopol 934P and sodium CMC, were taken as synergistic factors. The 3-D response surfaces and 2-D contour plots indicated significant effect of both the polymers on ex vivo bioadhesive strength of tablet against porcine gastric mucosa, diffusional release exponent and drug release extension. The optimized drug delivery formulation was selected by feasibility and grid searches based on maximization of the response variables. Validation of drug delivery optimization study using experimental runs indicated high prognostic ability of the chosen experimental design. Besides unraveling the effect of the two factors on various response variables, the study helped in finding the "optimized" formulation with excellent bioadhesive strength and extended release for 24 h, holding immense promise for once-a-day gastroretentive CR formulation and minimizing fluctuations in plasma drug levels.

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À propos des auteurs

Dr Bhupinder Singh Bhoop, Prof and Dean at Panjab University, India, is globally acclaimed for drug delivery. He has to his credit 110 publications, 7 book chapters, 4 patents and 13 research projects. He has delivered over 100 talks and presented 130 papers the world over. On Editorial Board of 12 journals, he has received several awards too.

Dr Bhupinder Singh Bhoop, Prof and Dean at Panjab University, India, is globally acclaimed for drug delivery. He has to his credit 110 publications, 7 book chapters, 4 patents and 13 research projects. He has delivered over 100 talks and presented 130 papers the world over. On Editorial Board of 12 journals, he has received several awards too.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP Lambert Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
3838394259
ISBN 13 
9783838394251
Reliure
Broché
Nombre de pages
248
Coordonnées du fabricant
non disponible
Personne responsable
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