Articles liés à Lipid/saccharide complexes for drug delivery: Structure...

Lipid/saccharide complexes for drug delivery: Structure and Dynamics - Couverture souple

GERELLI, Yuri

 
9783838397528: Lipid/saccharide complexes for drug delivery: Structure and Dynamics
Couverture souple
ISBN 10 : 3838397525 ISBN 13 : 9783838397528
Editeur : LAP LAMBERT Academic Publishing, 2010

Synopsis

Since the mid '90s, colloidal carriers have been used as drug delivery systems for effective administration of drugs having biopharmaceutical problems, such as severe side effects, low stability in biological fluids, specific organ toxicity, low bioavailability or poor aqueous solubility. Encapsulation into nano-sized carriers not only protects the active species from chemical and enzymatic degradation, but also makes it possible to localize the release process and to tune its kinetics. Biocompatible drug delivery vectors can be built up using a variety of materials including polymers, lipids, gels and hydrogels and emulsions. Among them, great attention has been addressed to particles obtained from ionic lipids with polyelectrolytes as stabilizing agents. In this book the characterization of the structure and the local dynamics of lipid/saccharide vectors is presented. The size and surface characteristics of these nanoparticles have been optimized to increase their circulation time in the bloodstream and to improve the biodistribution of the drugs. The results should be useful for the development of advanced drug vectors and for the comprehension of their macroscopic functioning.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Since the mid '90s, colloidal carriers have been used as drug delivery systems for effective administration of drugs having biopharmaceutical problems, such as severe side effects, low stability in biological fluids, specific organ toxicity, low bioavailability or poor aqueous solubility. Encapsulation into nano-sized carriers not only protects the active species from chemical and enzymatic degradation, but also makes it possible to localize the release process and to tune its kinetics. Biocompatible drug delivery vectors can be built up using a variety of materials including polymers, lipids, gels and hydrogels and emulsions. Among them, great attention has been addressed to particles obtained from ionic lipids with polyelectrolytes as stabilizing agents. In this book the characterization of the structure and the local dynamics of lipid/saccharide vectors is presented. The size and surface characteristics of these nanoparticles have been optimized to increase their circulation time in the bloodstream and to improve the biodistribution of the drugs. The results should be useful for the development of advanced drug vectors and for the comprehension of their macroscopic functioning.

Biographie de l'auteur

Yuri Gerelli, PhD in Physics at Parma University (Italy). Main research techniques: Neutron diffraction and scattering, static and dynamic light scattering and X-ray scattering applied on soft matter systems. Now postdoctoral fellow in soft matter Physics at Parma University, Parma, Italy.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
3838397525
ISBN 13 
9783838397528
Reliure
Broché
Nombre de pages
148
Coordonnées du fabricant
non disponible
Personne responsable
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