Articles liés à IHC PROFILING OF CYTOKERATIN 8 AND CYTOKERATIN 18 IN...

IHC PROFILING OF CYTOKERATIN 8 AND CYTOKERATIN 18 IN ORAL CANCER - Couverture souple

Patil, Shankargouda

 
9783843352178: IHC PROFILING OF CYTOKERATIN 8 AND CYTOKERATIN 18 IN ORAL CANCER
Couverture souple
ISBN 10 : 3843352178 ISBN 13 : 9783843352178
Editeur : LAP LAMBERT Academic Publishing, 2010

Synopsis

The expression of simple epithelial cytokeratins 8 and 18 is normally seen in the embryonic cells and lost in adult squamous epithelium. CK 8 and 18 play a role in tumor progression and metastatic potential as these are expressed only in the poorly differentiated and not in well differentiated squamous cell carcinomas. It appears that increased expression of the embryonic or simple epithelial cytokeratins 8 and 18 in some way changes the phenotypic characteristics of stratified epithelial cells, resulting in malignant transformation. Presence of Cytokeratin 8 and 18 in poorly differentiated foci of Oral squamous cell carcinoma even in the absence of metastasis could indicate a poor prognosis in these patients. However they are of functional importance in malignancy of keratinocytes and could be related to tumor invasion and/or to changes in epithelial mesenchymal interactions.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The expression of simple epithelial cytokeratins 8 and 18 is normally seen in the embryonic cells and lost in adult squamous epithelium. CK 8 and 18 play a role in tumor progression and metastatic potential as these are expressed only in the poorly differentiated and not in well differentiated squamous cell carcinomas. It appears that increased expression of the embryonic or simple epithelial cytokeratins 8 and 18 in some way changes the phenotypic characteristics of stratified epithelial cells, resulting in malignant transformation. Presence of Cytokeratin 8 and 18 in poorly differentiated foci of Oral squamous cell carcinoma even in the absence of metastasis could indicate a poor prognosis in these patients. However they are of functional importance in malignancy of keratinocytes and could be related to tumor invasion and/or to changes in epithelial mesenchymal interactions.

Biographie de l'auteur

Presently Working as Asst.Professor,Dept of Oral Pathology in KLE Society?s Institute of Dental Sciences,Bangalore. Secretary, International Association of General Dentistry, Texas/ Bangalore Managing Editor World Journal of dentistry Advisory board member for Guident Magazine Editorial board member in the Journal of International Oral Health

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
3843352178
ISBN 13 
9783843352178
Reliure
Broché
Nombre de pages
108
Coordonnées du fabricant
non disponible
Personne responsable
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