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Stromal Cells Promote Bone Invasion in Ameloblastoma: stromal and tumor cell interaction and their subsequent role in bone invasion of ameloblastoma - Couverture souple

SATHI, GULSAN; Nagatsuka, Hitoshi

 
9783843357258: Stromal Cells Promote Bone Invasion in Ameloblastoma: stromal and tumor cell interaction and their subsequent role in bone invasion of ameloblastoma
Couverture souple
ISBN 10 : 3843357250 ISBN 13 : 9783843357258
Editeur : LAP LAMBERT Academic Publishing, 2010

Synopsis

To date, there are many reports about the tumor progression and local invasion of ameloblastoma as well as bone resorption induced by the tumor cells. However, those studies have not described in detailed the histological features of ameloblastoma in terms of stroma and bone invasion. In this book therefore, discuss the stromal type with their sub types. In ameloblastoma, stroma acts not only in bone resorption but also causes suppression of new bone formation. sFRP-2, a Wnt antagonist is the main factor for the impaired bone formation. And activating RANKL with the help of TGF-?1 induced osteoclastogenesis. It causes bone destruction without a proportional osteoblastic reaction, resulting in an uncoupling of the normal bone remodeling sequence. So, the final volume of the bone destruction was less with a large number of osteoblast. Therapies targeting the inhibition of sFRP-2 and RANKL may potentials be used in inhibiting ameloblastoma's growth as well as other osteolytic disease.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

To date, there are many reports about the tumor progression and local invasion of ameloblastoma as well as bone resorption induced by the tumor cells. However, those studies have not described in detailed the histological features of ameloblastoma in terms of stroma and bone invasion. In this book therefore, discuss the stromal type with their sub types. In ameloblastoma, stroma acts not only in bone resorption but also causes suppression of new bone formation. sFRP-2, a Wnt antagonist is the main factor for the impaired bone formation. And activating RANKL with the help of TGF-?1 induced osteoclastogenesis. It causes bone destruction without a proportional osteoblastic reaction, resulting in an uncoupling of the normal bone remodeling sequence. So, the final volume of the bone destruction was less with a large number of osteoblast. Therapies targeting the inhibition of sFRP-2 and RANKL may potentials be used in inhibiting ameloblastoma's growth as well as other osteolytic disease.

Biographie de l'auteur

Gulsan Ara Sathi, B.D.S., PhD: Studied in oral pathology at Okayama University, Japan. Post-doctoral fellow at oral pathology, graduate school of medicine, dentistry and pharmaceutical science, okayama university, Japan

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
3843357250
ISBN 13 
9783843357258
Reliure
Broché
Nombre de pages
56
Coordonnées du fabricant
non disponible
Personne responsable
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