Formulation and Evaluation of Ion Exchange Resin Based Soluble Ocusert: Ocular Insert of Moxifloxacin Hydrochloride: A Novel Approach for Controlled Drug Delivery System - Couverture souple

Parmar, Ramesh; Tank, H. M.

 
9783843363372: Formulation and Evaluation of Ion Exchange Resin Based Soluble Ocusert: Ocular Insert of Moxifloxacin Hydrochloride: A Novel Approach for Controlled Drug Delivery System
Couverture souple
ISBN 10 : 3843363374 ISBN 13 : 9783843363372
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

In recent years scientific and technological advances have been made in development of ocular controlled drug delivery system to overcome physiological adversities of conventional dosage form. The present investigation was focused to prepare resinate of moxifloxacin and ion exchange resign to increase the residence time and decrease the solubility of drug in ocular site and incorporated in ocular insert. Ocular insert was prepared by solvent casting method. Nine formulations of OCDDS were prepared with different concentration of polymer (HPMC, MC, and PVA). Prepared formulation was subjected to physicochemical evaluation test,In vitro release, In vivo release and accelerated stability study test. In vivo release of formulation BRF6 was shown 98.87 % at the end of 12th hrs. In vitro release of all the formulation was computed with release kinetic model to predict release rate.suggested that all formulation was followed anomalous diffusion mechanism. Optimized formulation (BRF6) was subjected to antimicrobial test and sterility test. Result clearly showed it was passed. Accelerated stability study indicated optimized formulation was stable for longer period of time.

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Présentation de l'éditeur

In recent years scientific and technological advances have been made in development of ocular controlled drug delivery system to overcome physiological adversities of conventional dosage form. The present investigation was focused to prepare resinate of moxifloxacin and ion exchange resign to increase the residence time and decrease the solubility of drug in ocular site and incorporated in ocular insert. Ocular insert was prepared by solvent casting method. Nine formulations of OCDDS were prepared with different concentration of polymer (HPMC, MC, and PVA). Prepared formulation was subjected to physicochemical evaluation test,In vitro release, In vivo release and accelerated stability study test. In vivo release of formulation BRF6 was shown 98.87 % at the end of 12th hrs. In vitro release of all the formulation was computed with release kinetic model to predict release rate.suggested that all formulation was followed anomalous diffusion mechanism. Optimized formulation (BRF6) was subjected to antimicrobial test and sterility test. Result clearly showed it was passed. Accelerated stability study indicated optimized formulation was stable for longer period of time.

Biographie de l'auteur

Ramesh B. Parmar, Assistant Professor and Head of Pharmaceutics Department at S. J. Thakkar Pharmacy College, Rajkot. Completed my Ph. D. Work under the Guidance of Dr. H. M. Tank from Saurashtra University. I have Presented 6 international Poster and published 15 national & international research paper. I have Guided 18 M. Pharm. Students.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3843363374
ISBN 13 
9783843363372
Reliure
Broché
Nombre de pages
84
Coordonnées du fabricant
non disponible
Personne responsable
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