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DNA Content Analysis and Invitro Cytotoxicity in Bladder Cancer Patients - Couverture souple

Varma, Saurabh

 
9783843364133: DNA Content Analysis and Invitro Cytotoxicity in Bladder Cancer Patients
Couverture souple
ISBN 10 : 3843364133 ISBN 13 : 9783843364133
Editeur : LAP LAMBERT Academic Publishing, 2010

Synopsis

Transitional Cell Carcinoma accounts for more than 90% of bladder cancer. DNA analysis is the second most important application of flow cytometry. DNA content of individual cells give information about their ploidy in tumours and the distribution of cells across the cell cycle. Tumor DNA content has been found to be of prognostic importance for patients with many malignant tumors, such as carcinoma of urinary bladder. In-vitro cytotoxic studies on patients own cultured tumor tissue cells was done for the optimum cytotoxic combination of chemotherapeutic drugs and immunomodulators. This study was proposed investigate the DNA content evaluation and invitro monitoring of cytotoxicity produced by various chemotherapeutic agents viz Doxorubicin, Mitomycin C and Cisplatin on cultured cancer cells of patients having superficial TCC, individually as well as in combination of immunomodulating agents BCG and interferon alpha- 2b.Out of 25 samples nine were were aneuploid, one diploid and one tetraploid.Grade II samples were 70%. Out of 22 samples on which cytotoxicity test performed, 36.4% showed maximum cytotoxicity to the combination therapy and 5 showed to BCG drug.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Transitional Cell Carcinoma accounts for more than 90% of bladder cancer. DNA analysis is the second most important application of flow cytometry. DNA content of individual cells give information about their ploidy in tumours and the distribution of cells across the cell cycle. Tumor DNA content has been found to be of prognostic importance for patients with many malignant tumors, such as carcinoma of urinary bladder. In-vitro cytotoxic studies on patients own cultured tumor tissue cells was done for the optimum cytotoxic combination of chemotherapeutic drugs and immunomodulators. This study was proposed investigate the DNA content evaluation and invitro monitoring of cytotoxicity produced by various chemotherapeutic agents viz Doxorubicin, Mitomycin C and Cisplatin on cultured cancer cells of patients having superficial TCC, individually as well as in combination of immunomodulating agents BCG and interferon alpha- 2b.Out of 25 samples nine were were aneuploid, one diploid and one tetraploid.Grade II samples were 70%. Out of 22 samples on which cytotoxicity test performed, 36.4% showed maximum cytotoxicity to the combination therapy and 5 showed to BCG drug.

Biographie de l'auteur

The author has completed his PhD from Central Drug Research Institute,India and then joined esteemed All India Institute of Medical Sciences, Delhi,India. He is now working as senior scientist in Indian Council of Medical Research,India .He has 15 research papers to his credit,and has been Guide and co-guide to one PhD,7 MSc and 2 DNB students.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
3843364133
ISBN 13 
9783843364133
Reliure
Broché
Nombre de pages
80
Coordonnées du fabricant
non disponible
Personne responsable
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