Articles liés à CONTROLLED RELEASE NIFEDIPINE MICROPARTICLES FROM STARCH...

CONTROLLED RELEASE NIFEDIPINE MICROPARTICLES FROM STARCH ACETATE: DESIGN AND EVALUATION OF A CONTROLLED RELEASE MICROPARTICLES FROM STARCH ACETATE - Couverture souple

Mukherjee, Swarupananda

 
9783843368247: CONTROLLED RELEASE NIFEDIPINE MICROPARTICLES FROM STARCH ACETATE: DESIGN AND EVALUATION OF A CONTROLLED RELEASE MICROPARTICLES FROM STARCH ACETATE
Couverture souple
ISBN 10 : 3843368244 ISBN 13 : 9783843368247
Editeur : LAP LAMBERT Academic Publishing, 2010

Synopsis

The present investigation involves development of a CR Nifedipine microparticulate system utilizing starch acetate as the rate controlling polymer. SA was manufactured in house form native starches and characterization for degree of substitution (dS) and acetyl content among other parameters. An emulsification solvent evaporation technique was followed to develop microparticles of varying drug- polymer ratio's with triethyl citrate plasticizers at different levels. The prepared microparticles were subjected to standard evaluation such as yield, particle size, surface topography, drug content and in vitro dissolution studies.The development formulations were subsequently optimized through a simplex lattice mixture design to predict the optimum formulations matching the target official release profiles. It was found that two blend of development formulations, namely F1: F5 (0.822:0.1780) and F5: F13 (0.041:0.959) could closely resemble official specification and hence were optimum. The developed multiparticulate systems of Nifedipine are expected to provide a better clinical option for treatment of persistent/chronic angina and hypertension.

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À propos de l'auteur

SWARUPANANDA MUKHERJEE, M.PHARM, MBA, IPR, DPQCQAM (PhD),Assistant Professor, NSHM College of Pharmaceutical Technology, Kolkata. He has also completed his IPR from Indian Institute of Science, Bangalore and MBA from National Institute of Business Management,Chennai.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
3843368244
ISBN 13 
9783843368247
Reliure
Broché
Nombre de pages
112
Coordonnées du fabricant
non disponible
Personne responsable
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