Articles liés à Endocrine Disruptors - A Major Medical Challenge: An...

Endocrine Disruptors - A Major Medical Challenge: An Impact of Endocrine Disruptors on Endocrine System: their Estrogenic Mechanism in In vitro and In vivo Models - Couverture souple

Dang, Hoang Vu

 
9783843370233: Endocrine Disruptors - A Major Medical Challenge: An Impact of Endocrine Disruptors on Endocrine System: their Estrogenic Mechanism in In vitro and In vivo Models
Couverture souple
ISBN 10 : 3843370230 ISBN 13 : 9783843370233
Editeur : LAP LAMBERT Academic Publishing, 2010

Synopsis

Exposure to Endocrine Disruptors (EDs) with estrogen like activities during late pregnancy can induce temporal and specific alterations in gene expression profiles in the uteri of dams and neonates, most likely reflecting the temporal susceptibility of the reproductive tract to estrogenic EDs in which some estrogen responsive expressed markedly in the uterus of neonates. In addition, results from our experiments demonstrate the involvement of various signaling pathways in response to E2 and EDs in vitro and in vivo. These EDs may trigger the induction of CaBP-9k, a useful biomarker for screening the estrogenicity of EDs, via an estrogen receptor mediated pathways in animal and cellular models. Furthermore, non-genomic pathways appear to be involved in the induction of CaBP-9k expression by estrogen or estrogenic compounds. Taken together, these results indicated that both genomic and non- genomic actions are required to induce and modulate an ED- response in vitro and in vivo in which non- genomic responses occur rapidly, often within minutes of exposure, whereas genomic responses are delayed and require at least several hours to become established.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Exposure to Endocrine Disruptors (EDs) with estrogen like activities during late pregnancy can induce temporal and specific alterations in gene expression profiles in the uteri of dams and neonates, most likely reflecting the temporal susceptibility of the reproductive tract to estrogenic EDs in which some estrogen responsive expressed markedly in the uterus of neonates. In addition, results from our experiments demonstrate the involvement of various signaling pathways in response to E2 and EDs in vitro and in vivo. These EDs may trigger the induction of CaBP-9k, a useful biomarker for screening the estrogenicity of EDs, via an estrogen receptor mediated pathways in animal and cellular models. Furthermore, non-genomic pathways appear to be involved in the induction of CaBP-9k expression by estrogen or estrogenic compounds. Taken together, these results indicated that both genomic and non- genomic actions are required to induce and modulate an ED- response in vitro and in vivo in which non- genomic responses occur rapidly, often within minutes of exposure, whereas genomic responses are delayed and require at least several hours to become established.

Biographie de l'auteur

Hoang Vu Dang earned his Master and continued his study for Ph.D. training program at Chungbuk National University in Korea. After graduate, he has been awarded U.S. NIH funded postdoctoral fellowship in University of Rhode Island. Currently, he is working as JSPS postdoctoral fellow in Research Team for Advanced Biologics of NIAH in JAPAN

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
3843370230
ISBN 13 
9783843370233
Reliure
Broché
Nombre de pages
116
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne