Prodrug Designing of NSAIDs: “Design, Synthesis and Biological Screening of Carrier Linked Prodrugs of Potent NSAIDs” - Couverture souple

Patil, Smita; Shirote, Dr. Pramod; Doijad, Dr. Rajendra

 
9783843370578: Prodrug Designing of NSAIDs: “Design, Synthesis and Biological Screening of Carrier Linked Prodrugs of Potent NSAIDs”
Couverture souple
ISBN 10 : 3843370575 ISBN 13 : 9783843370578
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Separation of therapeutic effects from toxicity is a valuable goal in the drug development process. Prodrug design is a part of the general drug discovery process, in which a unique combination of therapeutically active substances is observed to have desirable pharmacological effects. In human therapy prodrug designing has given successful results in overcoming undesirable properties like absorption, nonspecificity, and poor bioavailability and GIT toxicity. Prodrug design is opening new doors in the challenging field of drug discovery, revolutionizing the art of Drug development.In this dissertation work, Synthesis of amide prodrugs of Niflumic acid and Ketoprofen with Glucosamine was achieved in good yields by a simple technique.Here prodrug approach has been successfully applied in attaining the goal of minimized gastrointestinal toxicity without loss of desired anti-inflammatory activities of the drug.

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Présentation de l'éditeur

Separation of therapeutic effects from toxicity is a valuable goal in the drug development process. Prodrug design is a part of the general drug discovery process, in which a unique combination of therapeutically active substances is observed to have desirable pharmacological effects. In human therapy prodrug designing has given successful results in overcoming undesirable properties like absorption, nonspecificity, and poor bioavailability and GIT toxicity. Prodrug design is opening new doors in the challenging field of drug discovery, revolutionizing the art of Drug development.In this dissertation work, Synthesis of amide prodrugs of Niflumic acid and Ketoprofen with Glucosamine was achieved in good yields by a simple technique.Here prodrug approach has been successfully applied in attaining the goal of minimized gastrointestinal toxicity without loss of desired anti-inflammatory activities of the drug.

Biographie de l'auteur

Ms. Smita Patil has been working as Asst. Professor in Pharmaceutical Chemistry Department of Shree Santkrupa College of Pharmacy, Ghogaon-Karad. She has 2.2 years experience. She has completed M.Pharmacy from Shivaji University, Kolhapur. She has 6 publications which includes research and review papers in National and International journals.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3843370575
ISBN 13 
9783843370578
Reliure
Broché
Nombre de pages
104
Coordonnées du fabricant
non disponible
Personne responsable
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