Articles liés à Simultaneous Estimation of Drugs by RP-HPLC: SIMULTANEOUS...

Simultaneous Estimation of Drugs by RP-HPLC: SIMULTANEOUS ESTIMATION OF CIPROFLOXACIN.HCl, OFLOXACIN, TINIDAZOLE AND ORNIDAZOLE BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY - Couverture souple

Maithani, Mukesh

 
9783843375153: Simultaneous Estimation of Drugs by RP-HPLC: SIMULTANEOUS ESTIMATION OF CIPROFLOXACIN.HCl, OFLOXACIN, TINIDAZOLE AND ORNIDAZOLE BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Couverture souple
ISBN 10 : 3843375151 ISBN 13 : 9783843375153
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

A new, simple, rapid, selective, precise and accurate isocratic RP-HPLC assay has been developed for simultaneous estimation of Ciprofloxacin Hydrochloride, Ofloxacin, Tinidazole and Ornidazole in tablet formulations. The separation was achieved by using C-18 column (Phenomenax, 250 x 4.6mm i.d.) coupled with a guard column of same material, in mobile phase Acetonitrile: Water: Tri ethylamine (25:75). The pH of mobile phase was adjusted to 6.0 ± 0.1 with 50% ortho phosphoric acid. The flow rate was 1.0 mL.min-1 and the separated drugs were detected using UV detector at the wavelength of 300 nm. The retention time of Ciprofloxacin Hydrochloride, Ofloxacin, Tinidazole, and Ornidazole was noted to be 2.7, 3.5, 4.5 and 5.8 min, respectively, indicative of rather shorter analysis time. The method was validated as per ICH guidelines. The proposed method was found to be accurate, reproducible, and consistent. It was successfully applied for the analysis of these drugs in marketed formulations and could be effectively used for the routine analysis of formulations containing any one of the above drugs, or a combination, without any alteration in the chromatographic conditions.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

A new, simple, rapid, selective, precise and accurate isocratic RP-HPLC assay has been developed for simultaneous estimation of Ciprofloxacin Hydrochloride, Ofloxacin, Tinidazole and Ornidazole in tablet formulations. The separation was achieved by using C-18 column (Phenomenax, 250 x 4.6mm i.d.) coupled with a guard column of same material, in mobile phase Acetonitrile: Water: Tri ethylamine (25:75). The pH of mobile phase was adjusted to 6.0 ± 0.1 with 50% ortho phosphoric acid. The flow rate was 1.0 mL.min-1 and the separated drugs were detected using UV detector at the wavelength of 300 nm. The retention time of Ciprofloxacin Hydrochloride, Ofloxacin, Tinidazole, and Ornidazole was noted to be 2.7, 3.5, 4.5 and 5.8 min, respectively, indicative of rather shorter analysis time. The method was validated as per ICH guidelines. The proposed method was found to be accurate, reproducible, and consistent. It was successfully applied for the analysis of these drugs in marketed formulations and could be effectively used for the routine analysis of formulations containing any one of the above drugs, or a combination, without any alteration in the chromatographic conditions.

Biographie de l'auteur

Mukesh Maithani did his Master of Pharmacy in 2007 from NIEC (UP Technical University) Lucknow. He is working as Assistant Professor in Shobhit University, Meerut and also pursuing PhD in Pharmaceutical Sciences from the same. He has published number of research and review articles in Journals national and international of repute.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3843375151
ISBN 13 
9783843375153
Reliure
Broché
Nombre de pages
140
Coordonnées du fabricant
non disponible
Personne responsable
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