Articles liés à CYSTEINE PROTEINASE (CP- 30) PROTEIN OF TRICHOMONAS...

CYSTEINE PROTEINASE (CP- 30) PROTEIN OF TRICHOMONAS VAGINALIS: In-silico Homology Modeling and Docking study - Couverture souple

MISRA, RAHUL; SUNDRIYAL, RUCHI; PRAKASH DWIVEDI, SURYA

 
9783843386289: CYSTEINE PROTEINASE (CP- 30) PROTEIN OF TRICHOMONAS VAGINALIS: In-silico Homology Modeling and Docking study
Couverture souple
ISBN 10 : 3843386285 ISBN 13 : 9783843386289
Editeur : LAP LAMBERT Academic Publishing, 2010

Synopsis

CP30 protein plays an important role in the establishment of host parasite relationship in Trichomoniasis. In the present work, single letter amino acid sequence of CP30 protein of T. vaginalis (ACC.No.NP_057852) was retrieved from protein database of NCBI, taken as a target protein sequence. Modeling of 3D structure of CP30 protein performed related to the target sequence using PSI-BLAST.As a consequence of number of hits, potential template structure (PDB-ID: 1K30), followed by calculation for energy and root mean square deviation (RMSD) of the specific model. Subsequently, various inhibitors were docked employing AutoDock to CP30 protein structure determined by comparative homology modeling. Auto Dock 3.05' was used for docking and calculation of the energy maps. From inhibitor optimization and docking studies, suitable inhibitor sphingosine is hunted. CP30 binds by the designed inhibitor; it may be very successful drug for CP30 protein inhibition. This work on inhibitor optimization will be a platform for the further studies on molecular mechanism of HIV infection & for most cost effective drug designing & for finding the inhibitor against this sexual transmitting disease.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

CP30 protein plays an important role in the establishment of host parasite relationship in Trichomoniasis. In the present work, single letter amino acid sequence of CP30 protein of T. vaginalis (ACC.No.NP_057852) was retrieved from protein database of NCBI, taken as a target protein sequence. Modeling of 3D structure of CP30 protein performed related to the target sequence using PSI-BLAST.As a consequence of number of hits, potential template structure (PDB-ID: 1K30), followed by calculation for energy and root mean square deviation (RMSD) of the specific model. Subsequently, various inhibitors were docked employing AutoDock to CP30 protein structure determined by comparative homology modeling. Auto Dock 3.05' was used for docking and calculation of the energy maps. From inhibitor optimization and docking studies, suitable inhibitor sphingosine is hunted. CP30 binds by the designed inhibitor; it may be very successful drug for CP30 protein inhibition. This work on inhibitor optimization will be a platform for the further studies on molecular mechanism of HIV infection & for most cost effective drug designing & for finding the inhibitor against this sexual transmitting disease.

Biographie de l'auteur

Rahul Misra, B.Tech in Biotechnology from Uttar Pradesh Technical University, Lucknow,INDIA , M.Tech in Biotechnology from National Institute of Technology, Durgapur,West Bengal,INDIA. Area of Interests are Clinical Bioinformatcs, Environmental Biotechnology.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
3843386285
ISBN 13 
9783843386289
Reliure
Broché
Nombre de pages
72
Coordonnées du fabricant
non disponible
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