Understanding Tertiary Interactions In Protein Structures: Use of Computational Methods and Techniques - Couverture souple

Bawa, Tejdeep Singh

 
9783843394031: Understanding Tertiary Interactions In Protein Structures: Use of Computational Methods and Techniques
Couverture souple
ISBN 10 : 3843394032 ISBN 13 : 9783843394031
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

Three-dimensional structures of proteins are the support of their biological functions.Their folds are stabilized by contacts between residues.Inner protein contacts are generally described through direct atomic contacts,while contact prediction methods mainly used inter-C? distances. During the process of protein folding,the amino acid residues along the polypeptide chain interact with each other in a cooperative manner to form a stable native structure.The knowledge about inter-residue interactions in protein structures is helpful to understand the mechanism of protein folding and stability.It provides valuable insights for understanding protein folding and de novo protein design.I analyzed protein contacts on a high quality non-redundant pdbs drawn from protein databank using various criteria. I have computed the average number of contacts depending on the distance threshold to define a contact.Preferential contacts between types of amino acids have been highlighted. Detailed analysis have been done concerning the proximity of contacts in the sequence,the size of the proteins and fold classes.The strongest differences have been extracted,highlighting important residues.

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Présentation de l'éditeur

Three-dimensional structures of proteins are the support of their biological functions.Their folds are stabilized by contacts between residues.Inner protein contacts are generally described through direct atomic contacts,while contact prediction methods mainly used inter-C? distances. During the process of protein folding,the amino acid residues along the polypeptide chain interact with each other in a cooperative manner to form a stable native structure.The knowledge about inter-residue interactions in protein structures is helpful to understand the mechanism of protein folding and stability.It provides valuable insights for understanding protein folding and de novo protein design.I analyzed protein contacts on a high quality non-redundant pdbs drawn from protein databank using various criteria. I have computed the average number of contacts depending on the distance threshold to define a contact.Preferential contacts between types of amino acids have been highlighted. Detailed analysis have been done concerning the proximity of contacts in the sequence,the size of the proteins and fold classes.The strongest differences have been extracted,highlighting important residues.

Biographie de l'auteur

Tejdeep is currently reading for a MA degree in Biomedical Informatics at Columbia University,completed his B.Tech in Computer Science and Engineering from GGSIP University,Delhi. Tejdeep has worked as a Research Asst. at SCFBio,IIT Delhi,and currently works at the Honig Lab,Center for Computational Biology and Bioinformatics at Columbia University

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3843394032
ISBN 13 
9783843394031
Reliure
Broché
Nombre de pages
64
Coordonnées du fabricant
non disponible
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