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The Role of Onion Extracts in The Prevention of Stroke: Neuroprotective effect of onion extracts - Couverture souple

Shri, Richa; Singh Bora, Kundan

 
9783844302363: The Role of Onion Extracts in The Prevention of Stroke: Neuroprotective effect of onion extracts
Couverture souple
ISBN 10 : 3844302360 ISBN 13 : 9783844302363
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

Stroke is the second leading cause of death in the world. Ischemic stroke is characterized by rapid onset of neurological injury due to interruption of blood flow to the brain. Free radicals have been implicated in cerebral ischemia and reperfusion- induced neuronal injury. Hence anti-oxidants have shown neuroprotective effect.The present study investigates the effect of methanolic extracts of a natural anti-oxidant plant - Allium cepa on ischemia and reperfusion induced cerebral injury. Global cerebral ischemia was induced by bilateral carotid artery occlusion for 10 min followed by reperfusion for 24 hr. Cerebral infarct size was estimated using triphenyltetrazolium chloride staining. TBARS assay was employed to measure oxidative stress. Elevated plus maze was employed to evaluate short-term memory. Motor incoordination was evaluated using inclined-beam walking test.Pretreatment with onion extracts reduced cerebral infarct size, attenuated impairment in short term memory and motor coordination along with a decrease in mitochondrial TBARS. Hence, antioxidant plant extracts that attenuate cerebral injury may play an important role in neuroprotection.

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Présentation de l'éditeur

Stroke is the second leading cause of death in the world. Ischemic stroke is characterized by rapid onset of neurological injury due to interruption of blood flow to the brain. Free radicals have been implicated in cerebral ischemia and reperfusion- induced neuronal injury. Hence anti-oxidants have shown neuroprotective effect.The present study investigates the effect of methanolic extracts of a natural anti-oxidant plant - Allium cepa on ischemia and reperfusion induced cerebral injury. Global cerebral ischemia was induced by bilateral carotid artery occlusion for 10 min followed by reperfusion for 24 hr. Cerebral infarct size was estimated using triphenyltetrazolium chloride staining. TBARS assay was employed to measure oxidative stress. Elevated plus maze was employed to evaluate short-term memory. Motor incoordination was evaluated using inclined-beam walking test.Pretreatment with onion extracts reduced cerebral infarct size, attenuated impairment in short term memory and motor coordination along with a decrease in mitochondrial TBARS. Hence, antioxidant plant extracts that attenuate cerebral injury may play an important role in neuroprotection.

Biographie de l'auteur

Dr Richa Shri teaches at the Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India. She studied from UIPS,Chandigarh. Her special areas of interest are evaluation of plants with neuroprotective effect and antianxiety activity and validation of traditional remedies. Mr KS Bora teaches at LR college, Solan.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3844302360
ISBN 13 
9783844302363
Reliure
Broché
Nombre de pages
100
Coordonnées du fabricant
non disponible
Personne responsable
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