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Malaria Vaccine Development: A Recombinant BCG-Based Vaccine Expressing Blood-Stage Antigen of P. Falciparum - Couverture souple

Abdullah, Nurul Asma; Mohd Nor, Norazmi

 
9783844304862: Malaria Vaccine Development: A Recombinant BCG-Based Vaccine Expressing Blood-Stage Antigen of P. Falciparum
Couverture souple
ISBN 10 : 384430486X ISBN 13 : 9783844304862
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

Vaccine development against blood-stage antigens is aimed at inducing inhibitory antibodies towards the circulating merozoites, thus preventing them from infecting red blood cells. One such blood stage candidate is the 19 kDa C-terminus of merozoite surface protein-1 (MSP-1C). MSP-1C has been shown to induce both inhibitory as well as blocking antibodies, the latter blocking the protective effects of the former. Inhibitory antibodies will bind to MSP-1C and inhibit merozoite invasion of red blood cell but the binding of blocking antibodies can prevent binding of inhibitory antibodies thereby allowing the parasite to invade an erythrocyte. This book provides some information regarding the development of blood-stage malaria vaccine based on mutated version of MSP-1C which induces inhibitory antibodies against malarial parasite. The use of live recombinant Mycobacterium bovis bacille Calmette Guerin as a vaccine vehicle was also described in this book. The rBCG expressing the mutated version of MSP-1C was found to induce some level of protections against P. falciparum; thus paving the way for the rational use of rBCG as a blood-stage malaria vaccine candidate.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Vaccine development against blood-stage antigens is aimed at inducing inhibitory antibodies towards the circulating merozoites, thus preventing them from infecting red blood cells. One such blood stage candidate is the 19 kDa C-terminus of merozoite surface protein-1 (MSP-1C). MSP-1C has been shown to induce both inhibitory as well as blocking antibodies, the latter blocking the protective effects of the former. Inhibitory antibodies will bind to MSP-1C and inhibit merozoite invasion of red blood cell but the binding of blocking antibodies can prevent binding of inhibitory antibodies thereby allowing the parasite to invade an erythrocyte. This book provides some information regarding the development of blood-stage malaria vaccine based on mutated version of MSP-1C which induces inhibitory antibodies against malarial parasite. The use of live recombinant Mycobacterium bovis bacille Calmette Guerin as a vaccine vehicle was also described in this book. The rBCG expressing the mutated version of MSP-1C was found to induce some level of protections against P. falciparum; thus paving the way for the rational use of rBCG as a blood-stage malaria vaccine candidate.

Biographie de l'auteur

Nurul Asma Abdullah, BSc (HON), PhD; Lecturer of Microbiology and Immunology at Universiti Sains Malaysia, Malaysia. Norazmi Mohd Nor, BSc (HON), PhD; Professor in Molecular Immunology at Universiti Sains Malaysia.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
384430486X
ISBN 13 
9783844304862
Reliure
Broché
Nombre de pages
180
Coordonnées du fabricant
non disponible
Personne responsable
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