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Formulation Strategies for dissolution enhancement of insoluble drugs: Dissolution enhancement of challenging drugs which are practically insoluble in gastric fluid and high permeable through stomach - Couverture souple

Patel, Rajnikant; Patel, Madhabhai; Patel, Natvarlal

 
9783844310696: Formulation Strategies for dissolution enhancement of insoluble drugs: Dissolution enhancement of challenging drugs which are practically insoluble in gastric fluid and high permeable through stomach
Couverture souple
ISBN 10 : 384431069X ISBN 13 : 9783844310696
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

Dissolution is important parameter to achieve desired concentration of drug in systemic circulation for elicit pharmacological response. The formulation of poorly soluble drugs has been the subjects of much research, as approximately 40% of new chemical entities develop in pharmaceutical industries are insoluble in nature. In the present investigation drugs which are practically insoluble in gastric fluid and having high permeability through stomach were selected. The rational for selecting such type was ?Drugs which are only permeable through stomach but due to its solubility limitation in gastric fluid they can not enter in to systemic circulation, further more gastric empting time is ranging form 30 mins to 2 hrs after this time drugs enter in to small intestine where they can soluble but can not permeable through its membrane due to its permeation limitation?. To improve dissolution of such drugs in stomach are challenging and rational. Attempts were made to prepare formulations which would dissolved completely within 30 minutes or retain in stomach for more than 2 hrs if drugs can not soluble in 2 hrs even after addition of solubilising enhancing excipients.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Dissolution is important parameter to achieve desired concentration of drug in systemic circulation for elicit pharmacological response. The formulation of poorly soluble drugs has been the subjects of much research, as approximately 40% of new chemical entities develop in pharmaceutical industries are insoluble in nature. In the present investigation drugs which are practically insoluble in gastric fluid and having high permeability through stomach were selected. The rational for selecting such type was ?Drugs which are only permeable through stomach but due to its solubility limitation in gastric fluid they can not enter in to systemic circulation, further more gastric empting time is ranging form 30 mins to 2 hrs after this time drugs enter in to small intestine where they can soluble but can not permeable through its membrane due to its permeation limitation?. To improve dissolution of such drugs in stomach are challenging and rational. Attempts were made to prepare formulations which would dissolved completely within 30 minutes or retain in stomach for more than 2 hrs if drugs can not soluble in 2 hrs even after addition of solubilising enhancing excipients.

Biographie de l'auteur

Dr.Rajnikant C.Patel M.Pharm, Ph.D. Assistant Professor Department of Pharmaceutics Kalol Institute of Pharmacy, Kalol, India.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
384431069X
ISBN 13 
9783844310696
Reliure
Broché
Nombre de pages
180
Coordonnées du fabricant
non disponible
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