Estimation of Dorzolamide and Timolol in Eye Drops by a RP-HPLC Method: Analysis of Dorzolamide and Timolol Eye Drop - Couverture souple

Wanare, Ravi

Couverture souple

ISBN 10 : 3844314148 ISBN 13 : 9783844314144

Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

A rapid, simple, accurate and economic High Performance Liquid Chromatographic analysis method has been developed for simultaneous estimation of Dorzolamide Hydrochloride (HCl) and Timolol Maleate in eye drop dosage forms is highly desirable to support formulation screening and quality control. The chromatography system used a reversed phase with C-18 column. The sample was analyzed using methanol: 1-octane sulphonic acid buffer, in the ratio of 55:45 as a mobile phase at a flow rate of 1.0 ml/min and detection with UV/Visible detector at two fixed wavelength (254.0 nm for Dorzolamide HCl and 295.0 nm for Timolol Maleate). The concentrations of these drugs were evaluated in marketed formulation by using simultaneous method. The present book describes the simultaneous estimation method of Dorzolamide Hydrochloride and Timolol Maleate in eye drop dosage form. The simultaneous estimation method given good recovery (accuracy), precision, linearity. Hence the method successfully used for quality control and routine analysis of drugs in eye drops dosage forms

A propos du livre

À propos de l'auteur

Prof.Ravi S. Wanare possess over 14 years of experience in teaching the subject of Organic, Medicinal and Analytical Chemistry to B.Pharm and M.Pharm students.Also published about 18 research papers in national and International journals.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2012
• Langue: anglais
• ISBN 10: 3844314148
• ISBN 13: 9783844314144
• Reliure: Broché
• Nombre de pages: 92
• Coordonnées du fabricant: non disponible
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