Effects of Analgesics on Acute Inflammatory Muscle Hyperalgesia: NSAIDs and Acute Inflammatory Muscle Hyperalgesia - Couverture souple

CHOPADE, ATUL; Sayyad, Fahim; Naikwade, Nilofar

 
9783844314298: Effects of Analgesics on Acute Inflammatory Muscle Hyperalgesia: NSAIDs and Acute Inflammatory Muscle Hyperalgesia
Couverture souple
ISBN 10 : 3844314296 ISBN 13 : 9783844314298
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

Pain associated with muscoskeletal conditions often induce disability and represent a significant financial burden to society in terms of health care costs and lost productivity. On the other hand, Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs worldwide to treat pain and inflammation. NSAIDs inhibit prostaglandin formation through inhibition of both the COX-1 and COX-2 enzymes. It has been reported that blocking constitutive spinal COX-2 before tissue injury may reduce the initial peripheral and central sensitization that occurs after tissue injury. The present study demonstrated the effects of COX inhibitors on spinally mediated hyperalgesia in models of acute inflammatory muscle hyperalgesia. The clinical relevancy of the observations in present work is emphasized by results that clearly demonstrate that nonselective COX inhibitors or COX-2-selective inhibitors have similar effects on the reversal of thermal hyperalgesia on acute model of muscle hyperalgesia. The NSAIDs showed significant effects on Maximum Possible Effectiveness, Analgesia and Antihyperalgesia.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Pain associated with muscoskeletal conditions often induce disability and represent a significant financial burden to society in terms of health care costs and lost productivity. On the other hand, Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs worldwide to treat pain and inflammation. NSAIDs inhibit prostaglandin formation through inhibition of both the COX-1 and COX-2 enzymes. It has been reported that blocking constitutive spinal COX-2 before tissue injury may reduce the initial peripheral and central sensitization that occurs after tissue injury. The present study demonstrated the effects of COX inhibitors on spinally mediated hyperalgesia in models of acute inflammatory muscle hyperalgesia. The clinical relevancy of the observations in present work is emphasized by results that clearly demonstrate that nonselective COX inhibitors or COX-2-selective inhibitors have similar effects on the reversal of thermal hyperalgesia on acute model of muscle hyperalgesia. The NSAIDs showed significant effects on Maximum Possible Effectiveness, Analgesia and Antihyperalgesia.

Biographie de l'auteur

Atul R. Chopade, He is presently working as Asst. Professor,at Dept. of Pharmacology, Rajarambapu College of Pharmacy, Kasegaon, taluka- Walwa, Dist- Sangli. 415404 MS India. His areas of research are Experimental Pharmacology and Pain Neurobiology and has published more than 30 research & reviews articles in national and international journals. .

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3844314296
ISBN 13 
9783844314298
Reliure
Broché
Nombre de pages
68
Coordonnées du fabricant
non disponible
Personne responsable
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