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Gene Expression and Splicing Efficiency: Gene Expression and Splicing Efficiency - Couverture souple

Ma, Pinchao

 
9783844315837: Gene Expression and Splicing Efficiency: Gene Expression and Splicing Efficiency
Couverture souple
ISBN 10 : 3844315837 ISBN 13 : 9783844315837
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

Most eukaryotic protein-coding genes are split into exons and introns, and introns need to be spliced for the production of mature mRNA by pre-mRNA splicing. Pre-mRNA splicing is very important for eukaryotic gene expression, because it is not only a key step in producing mature mRNA, but can also affect transcription and translation. The purpose of this study is to investigate the relationship between gene expression and splicing efficiency since the relationship has not been studied systematically from a bioinformatic approach. In this thesis research, we focus on the question of how gene expression would constrain the evolution of three principal splicing signals: the donor splice site, the acceptor splice site, and the branchpoint sequence (BPS).

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Présentation de l'éditeur

Most eukaryotic protein-coding genes are split into exons and introns, and introns need to be spliced for the production of mature mRNA by pre-mRNA splicing. Pre-mRNA splicing is very important for eukaryotic gene expression, because it is not only a key step in producing mature mRNA, but can also affect transcription and translation. The purpose of this study is to investigate the relationship between gene expression and splicing efficiency since the relationship has not been studied systematically from a bioinformatic approach. In this thesis research, we focus on the question of how gene expression would constrain the evolution of three principal splicing signals: the donor splice site, the acceptor splice site, and the branchpoint sequence (BPS).

Biographie de l'auteur

Pinchao has multiple backgrounds in Bioinformatics, Computer Science, Biology, and Statistics. Pinchao has written and successfully defended this thesis, and finally received a Master of Science degree at the University of Ottawa.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3844315837
ISBN 13 
9783844315837
Reliure
Broché
Nombre de pages
80
Coordonnées du fabricant
non disponible
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