Articles liés à Reinventing The Breast Cancer: A System Biology Approach

Reinventing The Breast Cancer: A System Biology Approach - Couverture souple

Kumar, Amrendar; Singh, Abhilahsa; Bhattacharjee, Biplab

 
9783844323047: Reinventing The Breast Cancer: A System Biology Approach
Couverture souple
ISBN 10 : 384432304X ISBN 13 : 9783844323047
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

Cancer being a highly complex combination of diseases, it can be studied and understood better by the complex networks in System/Network biology. Here is a novel step to study the relation between drug target network and the corresponding drug network using the advanced concept of proteomics and systems biology and to develop an effective strategy for cancer prevention.104 antimutagens were collected from literature survey. Of this only 81 structure were available and taken from the Pubchem database. The PDB ids of the Breast cancer genes were taken. Docking was performed with the help of Quantum docking software and the docking scores were obtained. The list of gene ids obtained is loaded into the VISANT application. From the data obtained and the various analysis done the antimutagen Beta-Sitosterol obtained from the Black cumin Seeds (Nigella Sativa) shows least RMSD value with the protein 2I1J corresponding to the gene UTP14A indicating that Breast cancer specific drugs are specific for the particular disease gene and not random among the networks. The ligands (Antimutagens) show good response to the specific type of cancer.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Cancer being a highly complex combination of diseases, it can be studied and understood better by the complex networks in System/Network biology. Here is a novel step to study the relation between drug target network and the corresponding drug network using the advanced concept of proteomics and systems biology and to develop an effective strategy for cancer prevention.104 antimutagens were collected from literature survey. Of this only 81 structure were available and taken from the Pubchem database. The PDB ids of the Breast cancer genes were taken. Docking was performed with the help of Quantum docking software and the docking scores were obtained. The list of gene ids obtained is loaded into the VISANT application. From the data obtained and the various analysis done the antimutagen Beta-Sitosterol obtained from the Black cumin Seeds (Nigella Sativa) shows least RMSD value with the protein 2I1J corresponding to the gene UTP14A indicating that Breast cancer specific drugs are specific for the particular disease gene and not random among the networks. The ligands (Antimutagens) show good response to the specific type of cancer.

Biographie de l'auteur

Amrendar Kumar And Abhilasha Singh Amity Institute of Biotechnology, Amity University, Lucknow Biplab Bhattacharjee IOCB, Bangalore

Amrendar Kumar And Abhilasha Singh Amity Institute of Biotechnology, Amity University, Lucknow Biplab Bhattacharjee IOCB, Bangalore

Amrendar Kumar And Abhilasha Singh Amity Institute of Biotechnology, Amity University, Lucknow Biplab Bhattacharjee IOCB, Bangalore

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
384432304X
ISBN 13 
9783844323047
Reliure
Broché
Nombre de pages
148
Coordonnées du fabricant
non disponible
Personne responsable
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