Oroxylum indicum: Exploring Anticancer Potential - Couverture souple

Joshi, Ms. Dipti; Kala Suhas Kulkarni, Dr.; Kishori Apte, Dr.

Couverture souple

ISBN 10 : 3844328076 ISBN 13 : 9783844328073

Editeur : LAP Lambert Academic Publishing, 2011

Synopsis

Hepatocellular Carcinoma represents about 4% of all malignancies worldwide. A number of chemopreventive phytochemicals have been identified which react with prooxidants and prevent damages to DNA thereby preventing the onset of various diseases. Thioacetamide, a model hepatotoxicant, undergoes metabolic activation to form thioacetamide sulfoxide and further metabolized to form thioacetamide-S,S,- oxide thus initiating hepatocellular necrosis and further hepatocarcinogenesis. Thioacetamide thus produces oxidative stress on liver and causes hepatocellular carcinoma. This oxidative stress can be reversed by the use of antioxidants. Thus, the aim of this work was to evaluate the anticancer activity of hydroalcoholic extract prepared from Oroxylum indicum, correlating the biochemical and histological changes in thioacetamide induced hepatocellular carcinoma in female Sprague Dawley rats. This research work should help shed some light on cancer research and experimental model development for hepatocellular carcinoma, and should be especially useful to research scholars, scientists and students working on hepatocellular carcinoma in experimental animals.

A propos du livre

À propos des auteurs

Master of Pharmaceutical Sciences in Pharmacology, School of Pharmacy and Technology Management, NMIMS, Mumbai Dr. Kala Suhas Kulkarni, Head of the department, Department of Clinical Pharmacy, NMIMS, Mumbai Dr.Kishori Apte, Director, National Toxicology Centre, Pune

Master of Pharmaceutical Sciences in Pharmacology, School of Pharmacy and Technology Management, NMIMS, Mumbai Dr. Kala Suhas Kulkarni, Head of the department, Department of Clinical Pharmacy, NMIMS, Mumbai Dr.Kishori Apte, Director, National Toxicology Centre, Pune

Master of Pharmaceutical Sciences in Pharmacology, School of Pharmacy and Technology Management, NMIMS, Mumbai Dr. Kala Suhas Kulkarni, Head of the department, Department of Clinical Pharmacy, NMIMS, Mumbai Dr.Kishori Apte, Director, National Toxicology Centre, Pune

Détails de l'édition

• Éditeur: LAP Lambert Academic Publishing
• Date d'édition: 2011
• Langue: anglais
• ISBN 10: 3844328076
• ISBN 13: 9783844328073
• Reliure: Broché
• Nombre de pages: 72
• Coordonnées du fabricant: non disponible
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