Articles liés à Unrevealing Endometrial Cancer: Insilico Drug Discovery...

Unrevealing Endometrial Cancer: Insilico Drug Discovery Approach on Endometrial Cancer - Couverture souple

R.M, Jayadeepa

 
9783844332186: Unrevealing Endometrial Cancer: Insilico Drug Discovery Approach on Endometrial Cancer
Couverture souple
ISBN 10 : 3844332189 ISBN 13 : 9783844332186
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

Traditionally, drugs were discovered by testing compounds synthesized in time consuming multi-step processes against a battery of in vivo biological screens. Promising compounds were then further studied in development, where their pharmaceutical properties, metabolism and potential toxicity were investigated. Here we present a study on herbal lead compounds and their potential binding affinity to the effectors molecules of major diseases like endometrial cancer. Clinical studies demonstrate a positive correlation between the extent of PDK1 and malignant progression of pre cancerous lesions in endometrial. Therefore, identification of effective, well-tolerated anti cancer inhibitor represents a rational chemo preventive strategy. This study has investigated the effects of naturally occurring compounds that inhibits the target. Our results reveal that these compounds use less energy to bind to the target and inhibit its activity than the commercial drugs used. Their high legend binding activity to the target introduce the prospect for their use in chemo preventive applications in addition they are freely available natural compounds that can be safely used to prevent disease.

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Présentation de l'éditeur

Traditionally, drugs were discovered by testing compounds synthesized in time consuming multi-step processes against a battery of in vivo biological screens. Promising compounds were then further studied in development, where their pharmaceutical properties, metabolism and potential toxicity were investigated. Here we present a study on herbal lead compounds and their potential binding affinity to the effectors molecules of major diseases like endometrial cancer. Clinical studies demonstrate a positive correlation between the extent of PDK1 and malignant progression of pre cancerous lesions in endometrial. Therefore, identification of effective, well-tolerated anti cancer inhibitor represents a rational chemo preventive strategy. This study has investigated the effects of naturally occurring compounds that inhibits the target. Our results reveal that these compounds use less energy to bind to the target and inhibit its activity than the commercial drugs used. Their high legend binding activity to the target introduce the prospect for their use in chemo preventive applications in addition they are freely available natural compounds that can be safely used to prevent disease.

Biographie de l'auteur

Jayadeepa.R.M, M.Sc: Studied Bioinformatics at Dr.G.R.Damodaran College of Science,Coimbatore,Tamilnadu,India; Research Scientist at Institute Of Computational Biology,Bangalore,India Areas of Interest : Insilico Drug Designing,Machine Learning, R Programming,Biological Networking,Microarray Data Analysis,Systems Biology,Sequence Analysis

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3844332189
ISBN 13 
9783844332186
Reliure
Broché
Nombre de pages
116
Coordonnées du fabricant
non disponible
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