DEVELOPMENT AND CHARACTERIZATION OF ROSIGLITAZONE NANOPARTICLES: Ionotropic Gelation and Double Desolvation Technique - Couverture souple

Singh, Vandana; Chaudhary, Amrendra; Ahmed, Shamim

 
9783844393682: DEVELOPMENT AND CHARACTERIZATION OF ROSIGLITAZONE NANOPARTICLES: Ionotropic Gelation and Double Desolvation Technique
Couverture souple
ISBN 10 : 3844393684 ISBN 13 : 9783844393682
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

Nanoparticles have gained much attention as a promising drug delivery system due to their unique properties. Rosiglitazone maleate, an antidiabetic agent, acts as a highly selective and potent agonist for PPAR receptors in target tissues for insulin action. In spite of its high efficiency, side effects limit the clinical use. To reduce the side effects of conventional dosage form, rosiglitazone loaded nanoparticles have been formulated. Nanoparticles were formulated by gelatin and chitosan via double desolvation and ionotropic gelation technique respectively, & subjected to photon correlation spectroscopy, transmission electron microscopy & encapsulation efficiency studies. These studies favorably revealed that the mean particle diameter of optimized formulation was 49 nm (gelatin) and 86 nm (chitosan) with spherical morphology. The optimized formulation demonstrated favorable in vitro prolonged release characteristics with zero order, diffusion and erosion mechanisms. Nanoparticles also showed excellent stability. Hence, the designed delivery system can be fine tuned on the depending clinical applications.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Nanoparticles have gained much attention as a promising drug delivery system due to their unique properties. Rosiglitazone maleate, an antidiabetic agent, acts as a highly selective and potent agonist for PPAR receptors in target tissues for insulin action. In spite of its high efficiency, side effects limit the clinical use. To reduce the side effects of conventional dosage form, rosiglitazone loaded nanoparticles have been formulated. Nanoparticles were formulated by gelatin and chitosan via double desolvation and ionotropic gelation technique respectively, & subjected to photon correlation spectroscopy, transmission electron microscopy & encapsulation efficiency studies. These studies favorably revealed that the mean particle diameter of optimized formulation was 49 nm (gelatin) and 86 nm (chitosan) with spherical morphology. The optimized formulation demonstrated favorable in vitro prolonged release characteristics with zero order, diffusion and erosion mechanisms. Nanoparticles also showed excellent stability. Hence, the designed delivery system can be fine tuned on the depending clinical applications.

Biographie de l'auteur

Mrs. Vandana Singh graduated from Dr.K.N.M.I.P.E.R, Modinagar, and post graduated from Bundelkhand University, Jhansi. She is having 1 year of industrial and 4 years of teaching experience. Currently working as Senior Lecturer at Translam Institute of Pharmaceutical Education and Research, Meerut, India.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3844393684
ISBN 13 
9783844393682
Reliure
Broché
Nombre de pages
92
Coordonnées du fabricant
non disponible
Personne responsable
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