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Development of a new inactivated virus vaccine: Case study for Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) - Couverture souple
Synopsis
This book outlines the different stages of vaccine development and focuses on molecular methods that can be used for screening and quality control for inactivated virus vaccines. First, a screening assay was developed to evaluate virus inactivation and preservation of the virion structure. Second, possible vaccine virus adaptation problems to a cell line are solved. This research is based on porcine reproductive and respiratory syndrome virus (PRRSV), but can be valuable for development of other vaccines as well.PRRSV leads to reproduction failure in sows and is associated with the respiratory disease complex in pigs. Although commercial vaccines exist, PRRSV is still difficult to control in the field. This can be due to modification of epitopes during the inactivation procedure or virus adaptation to a cell line.We developed a new inactivated PRRSV vaccine with virus grown on a PRRSV sensitive pig cell line to minimize mutations in viral structural proteins. Furthermore, we screened different inactivation methods for their ability to preserve viral entry-associated domains. These measures enabled us to select in vitro for the vaccine that afterwards showed best results in vivo.
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Présentation de l'éditeur
This book outlines the different stages of vaccine development and focuses on molecular methods that can be used for screening and quality control for inactivated virus vaccines. First, a screening assay was developed to evaluate virus inactivation and preservation of the virion structure. Second, possible vaccine virus adaptation problems to a cell line are solved. This research is based on porcine reproductive and respiratory syndrome virus (PRRSV), but can be valuable for development of other vaccines as well.PRRSV leads to reproduction failure in sows and is associated with the respiratory disease complex in pigs. Although commercial vaccines exist, PRRSV is still difficult to control in the field. This can be due to modification of epitopes during the inactivation procedure or virus adaptation to a cell line.We developed a new inactivated PRRSV vaccine with virus grown on a PRRSV sensitive pig cell line to minimize mutations in viral structural proteins. Furthermore, we screened different inactivation methods for their ability to preserve viral entry-associated domains. These measures enabled us to select in vitro for the vaccine that afterwards showed best results in vivo.
Biographie de l'auteur
Iris Delrue, PhD in Veterinary Sciences (vaccine development), M.Sc. Biotechnology at Ghent University, Belgium.
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Development of a new inactivated virus vaccine
Edité par
LAP LAMBERT Academic Publishing, 2011
ISBN 10 : 3845402822
ISBN 13 : 9783845402826
Neuf
Couverture souple
Vendeur : moluna, Greven, Allemagne
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Delrue IrisIris Delrue, PhD in Veterinary Sciences (vaccine development), M.Sc. Biotechnology at Ghent University, Belgium.This book outlines the different stages of vaccine development and focuses on molecular methods that can b. N° de réf. du vendeur 5480440
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Development of a new inactivated virus vaccine : Case study for Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)
Edité par
LAP LAMBERT Academic Publishing, 2011
ISBN 10 : 3845402822
ISBN 13 : 9783845402826
Neuf
Taschenbuch
Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - This book outlines the different stages of vaccine development and focuses on molecular methods that can be used for screening and quality control for inactivated virus vaccines. First, a screening assay was developed to evaluate virus inactivation and preservation of the virion structure. Second, possible vaccine virus adaptation problems to a cell line are solved. This research is based on porcine reproductive and respiratory syndrome virus (PRRSV), but can be valuable for development of other vaccines as well.PRRSV leads to reproduction failure in sows and is associated with the respiratory disease complex in pigs. Although commercial vaccines exist, PRRSV is still difficult to control in the field. This can be due to modification of epitopes during the inactivation procedure or virus adaptation to a cell line.We developed a new inactivated PRRSV vaccine with virus grown on a PRRSV sensitive pig cell line to minimize mutations in viral structural proteins. Furthermore, we screened different inactivation methods for their ability to preserve viral entry-associated domains. These measures enabled us to select in vitro for the vaccine that afterwards showed best results in vivo. N° de réf. du vendeur 9783845402826
Quantité disponible : 1 disponible(s)
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Development of a new inactivated virus vaccine
Edité par
LAP LAMBERT Academic Publishing Jul 2011, 2011
ISBN 10 : 3845402822
ISBN 13 : 9783845402826
Neuf
Taschenbuch
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book outlines the different stages of vaccine development and focuses on molecular methods that can be used for screening and quality control for inactivated virus vaccines. First, a screening assay was developed to evaluate virus inactivation and preservation of the virion structure. Second, possible vaccine virus adaptation problems to a cell line are solved. This research is based on porcine reproductive and respiratory syndrome virus (PRRSV), but can be valuable for development of other vaccines as well.PRRSV leads to reproduction failure in sows and is associated with the respiratory disease complex in pigs. Although commercial vaccines exist, PRRSV is still difficult to control in the field. This can be due to modification of epitopes during the inactivation procedure or virus adaptation to a cell line.We developed a new inactivated PRRSV vaccine with virus grown on a PRRSV sensitive pig cell line to minimize mutations in viral structural proteins. Furthermore, we screened different inactivation methods for their ability to preserve viral entry-associated domains. These measures enabled us to select in vitro for the vaccine that afterwards showed best results in vivo. 172 pp. Englisch. N° de réf. du vendeur 9783845402826
Quantité disponible : 2 disponible(s)
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Development of a new inactivated virus vaccine
Edité par
LAP LAMBERT Academic Publishing Jul 2011, 2011
ISBN 10 : 3845402822
ISBN 13 : 9783845402826
Neuf
Taschenbuch
Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. Neuware -This book outlines the different stages of vaccine development and focuses on molecular methods that can be used for screening and quality control for inactivated virus vaccines. First, a screening assay was developed to evaluate virus inactivation and preservation of the virion structure. Second, possible vaccine virus adaptation problems to a cell line are solved. This research is based on porcine reproductive and respiratory syndrome virus (PRRSV), but can be valuable for development of other vaccines as well.PRRSV leads to reproduction failure in sows and is associated with the respiratory disease complex in pigs. Although commercial vaccines exist, PRRSV is still difficult to control in the field. This can be due to modification of epitopes during the inactivation procedure or virus adaptation to a cell line.We developed a new inactivated PRRSV vaccine with virus grown on a PRRSV sensitive pig cell line to minimize mutations in viral structural proteins. Furthermore, we screened different inactivation methods for their ability to preserve viral entry-associated domains. These measures enabled us to select in vitro for the vaccine that afterwards showed best results in vivo.Books on Demand GmbH, Überseering 33, 22297 Hamburg 172 pp. Englisch. N° de réf. du vendeur 9783845402826
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Development of a new inactivated virus vaccine
Edité par
VDM Verlag Dr. Mueller Aktiengesellschaft & Co. KG, 2011
ISBN 10 : 3845402822
ISBN 13 : 9783845402826
Neuf
Couverture souple
Vendeur : Majestic Books, Hounslow, Royaume-Uni
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Etat : New. Print on Demand pp. 172 2:B&W 6 x 9 in or 229 x 152 mm Perfect Bound on Creme w/Gloss Lam. N° de réf. du vendeur 131707120
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Development of a new inactivated virus vaccine: Case study for Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)
Edité par
LAP LAMBERT Academic Publishing, 2011
ISBN 10 : 3845402822
ISBN 13 : 9783845402826
Neuf
paperback
Vendeur : Mispah books, Redhill, SURRE, Royaume-Uni
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paperback. Etat : New. New. book. N° de réf. du vendeur ERICA82938454028226
Quantité disponible : 1 disponible(s)