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Multiparticulate System For Peptic Ulcer: Novel Drug Delivery System For Helicobacter Pylori Induced Peptic Ulcer - Couverture souple

Pandit, Vinay; Suresh, Sarasija

 
9783845407241: Multiparticulate System For Peptic Ulcer: Novel Drug Delivery System For Helicobacter Pylori Induced Peptic Ulcer
Couverture souple
ISBN 10 : 3845407247 ISBN 13 : 9783845407241
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

The discovery of Helicobacter pylori as the cause of peptic ulcer has revolutionized anti-ulcer treatment. The current treatment includes a combination of antibiotics with proton pump inhibitors or H2 receptor antagonist1,2. Clarithromycin and omeprazole combination has become popular and best choice for treating peptic ulcer associated with H. pylori infection3. Gastro retentive dosage forms have the potential for increased residence in stomach along with site-specific drug delivery. Hydrodynamic drug delivery systems (HBS) are one such systems that has increased gastric residence providing an increased local action at the ulcer site4. Clarithromycin, effective in H.pylori infection treatment was chosen as model drug. Extended release and retention in upper gastro intestinal tract would be most advantageous, optimizing the combination therapy of peptic ulcer complicated with H.pylori. Omeprazole was formulated as fast dissolving enteric-coated pellets by using extrusion spheronisation technique. Enteric coating material used was Eudragit –30D-L-55.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The discovery of Helicobacter pylori as the cause of peptic ulcer has revolutionized anti-ulcer treatment. The current treatment includes a combination of antibiotics with proton pump inhibitors or H2 receptor antagonist1,2. Clarithromycin and omeprazole combination has become popular and best choice for treating peptic ulcer associated with H. pylori infection3. Gastro retentive dosage forms have the potential for increased residence in stomach along with site-specific drug delivery. Hydrodynamic drug delivery systems (HBS) are one such systems that has increased gastric residence providing an increased local action at the ulcer site4. Clarithromycin, effective in H.pylori infection treatment was chosen as model drug. Extended release and retention in upper gastro intestinal tract would be most advantageous, optimizing the combination therapy of peptic ulcer complicated with H.pylori. Omeprazole was formulated as fast dissolving enteric-coated pellets by using extrusion spheronisation technique. Enteric coating material used was Eudragit –30D-L-55.

Biographie de l'auteur

Mr Vinay Pandit,presently working in Al-Ameen College of Pharmacy, Bangalore , Karnataka, India is pursung his PhD under the guidance of Dr Sarasija Suresh of Al-Ameen college of Pharmacy, Bangalore. He has 7 years of teaching experience and has more than 10 publications and presentations in national and international journals/Conferences.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3845407247
ISBN 13 
9783845407241
Reliure
Broché
Nombre de pages
132
Coordonnées du fabricant
non disponible
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