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Multicomponent One Pot Green Synthesis of 1, 5-Benzodiazepines: Investigating various acids for its catalytic potential and their mechanism - Couverture souple

Sandhar, Akshdeep

 
9783845422589: Multicomponent One Pot Green Synthesis of 1, 5-Benzodiazepines: Investigating various acids for its catalytic potential and their mechanism
Couverture souple
ISBN 10 : 3845422580 ISBN 13 : 9783845422589
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Multicomponent Reactions (MCRs) are a promising and vital field of green chemistry. Benzodiazepines are widely used class of bioactive compounds due to their remarkable biological and pharmacological properties. However, many of the methods of synthesis of benzodiazepines suffer major or minor limitations like tedious work up procedure, applications of expensive and hazardous catalyst, long reaction times, unsatisfactory yields, require separation of the catalyst from the product and formation of side products. In our project, we have reviewed the various heterogenous and homogenous catalysts utilized for the synthesis of 1, 5-benzodizepines in the last decade and explored the novel, non-expensive, easily available, non toxic catalyst for the efficient synthesis of 1,5-benzodiazepines under solvent-free conditions. The catalytic efficiency of various acids studied, are categorized in four categories with their proposed mechanism of actions: Amino acids, Aliphatic acids, Aromatic acids and Miscellaneous acids. The remarkable features of these new acid catalysts are high yield, short reaction times, cleaner reaction profiles and high regioselectivity.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Multicomponent Reactions (MCRs) are a promising and vital field of green chemistry. Benzodiazepines are widely used class of bioactive compounds due to their remarkable biological and pharmacological properties. However, many of the methods of synthesis of benzodiazepines suffer major or minor limitations like tedious work up procedure, applications of expensive and hazardous catalyst, long reaction times, unsatisfactory yields, require separation of the catalyst from the product and formation of side products. In our project, we have reviewed the various heterogenous and homogenous catalysts utilized for the synthesis of 1, 5-benzodizepines in the last decade and explored the novel, non-expensive, easily available, non toxic catalyst for the efficient synthesis of 1,5-benzodiazepines under solvent-free conditions. The catalytic efficiency of various acids studied, are categorized in four categories with their proposed mechanism of actions: Amino acids, Aliphatic acids, Aromatic acids and Miscellaneous acids. The remarkable features of these new acid catalysts are high yield, short reaction times, cleaner reaction profiles and high regioselectivity.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3845422580
ISBN 13 
9783845422589
Reliure
Broché
Nombre de pages
136
Éditeur
Singh Rajesh K.
Coordonnées du fabricant
non disponible
Personne responsable
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