Articles liés à Expression of neutrophil elastase in relation to the...

Expression of neutrophil elastase in relation to the autoimmunity: to epidermal transglutaminase, BP180, BP230, desmoglein 1 and 3 in autoimmune blistering dermatoses - Couverture souple

Gornowicz-Porowska, Justyna

 
9783845433738: Expression of neutrophil elastase in relation to the autoimmunity: to epidermal transglutaminase, BP180, BP230, desmoglein 1 and 3 in autoimmune blistering dermatoses
Couverture souple
ISBN 10 : 3845433736 ISBN 13 : 9783845433738
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Activated inflammatory cells, especially neutrophils, may play a significant role in pathology of autoimmune bullous dermatoses by secreting proteases, e.g. neutrophil elastase (NE). However, the role of NE in relation to autoimmunity against particular autoantigens (anti-DSG1/DSG3 IgG in pemphigus, anti-BP180/BP230 IgG in bullous pemphigoid - BP, anti-eTG/tTG/npG IgA in dermatitis herpetiformis - DH) has not been clearly explained. The aim of this comparative work was to attempt to clarify the intertwined issue of cutaneous autoimmune NE-mediated inflammation in those diseases. Six different study groups were investigated and a range of biochemical/molecular techniques was used. Computational analysis of microscopic images was used to measure the NE expression. Statistical analysis showed that the intensity of cutaneous NE expression in pemphigus and BP was significantly lower than in DH, but it was not significantly different in pemphigus and BP. It seems that cutaneous NE-related inflammatory processes in both pemphigus and BP, characterised by autoimmunity to structural proteins, have lesser pathologic importance in comparison with DH, characterised by autoimmunity to enzymes.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Activated inflammatory cells, especially neutrophils, may play a significant role in pathology of autoimmune bullous dermatoses by secreting proteases, e.g. neutrophil elastase (NE). However, the role of NE in relation to autoimmunity against particular autoantigens (anti-DSG1/DSG3 IgG in pemphigus, anti-BP180/BP230 IgG in bullous pemphigoid - BP, anti-eTG/tTG/npG IgA in dermatitis herpetiformis - DH) has not been clearly explained. The aim of this comparative work was to attempt to clarify the intertwined issue of cutaneous autoimmune NE-mediated inflammation in those diseases. Six different study groups were investigated and a range of biochemical/molecular techniques was used. Computational analysis of microscopic images was used to measure the NE expression. Statistical analysis showed that the intensity of cutaneous NE expression in pemphigus and BP was significantly lower than in DH, but it was not significantly different in pemphigus and BP. It seems that cutaneous NE-related inflammatory processes in both pemphigus and BP, characterised by autoimmunity to structural proteins, have lesser pathologic importance in comparison with DH, characterised by autoimmunity to enzymes.

Biographie de l'auteur

Justyna Gornowicz-Porowska obtained her M. Sc. Eng. in biotechnology at the Poznan University of Life Sciences. At present, she is conducting the Ph.D. thesis under the supervision of Associate Professor Marian Dmochowski at Poznan University of Medical Sciences in Poland focusing on cutaneous pathophysiology of autoimmune blistering dermatoses.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3845433736
ISBN 13 
9783845433738
Reliure
Broché
Nombre de pages
136
Coordonnées du fabricant
non disponible
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