Role of the CD63 Expression Test on Basophils in Drug Allergy: CD63 expression test on basophils in drug allergy diagnosis - Couverture souple

Kvedariene, Violeta; Arnoux, Bernadrd; Demoly, Pascal

 
9783845440040: Role of the CD63 Expression Test on Basophils in Drug Allergy: CD63 expression test on basophils in drug allergy diagnosis
Couverture souple
ISBN 10 : 384544004X ISBN 13 : 9783845440040
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Diagnosis of drug hypersensitivity is indeed based on history and clinical manifestations and on skin and drug provocation tests. There are limitations to the interpretation of in vivo tests as co-factors at the time of onset, the metabolism of drug, the presentation of haptens to the immune system may be different after epicutaneous or oral challenge. Therefore, biological tests would be a highly desirable solution for establishing the nature of the culprit agent. In the present work, the results of the CD63 expression tests on basophils were analysed using a novel distribution depending on the time delay between the reaction and the drug intake, the tested drug concentration and the chemical drug structure, in both immediate and non-immediate reactions. The importance of cut-off values was assessed in immediate and non-immediate reactions induced by “haptenic” molecules. The discordance between the results of specific IgE to β-lactams and the CD63 expression test on basophils was analysed in β-lactam allergic patients. The subgroup of patients with severe drug-induced reactions was assessed to evaluate the results of CD63 expression tests in clinical practice.

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Présentation de l'éditeur

Diagnosis of drug hypersensitivity is indeed based on history and clinical manifestations and on skin and drug provocation tests. There are limitations to the interpretation of in vivo tests as co-factors at the time of onset, the metabolism of drug, the presentation of haptens to the immune system may be different after epicutaneous or oral challenge. Therefore, biological tests would be a highly desirable solution for establishing the nature of the culprit agent. In the present work, the results of the CD63 expression tests on basophils were analysed using a novel distribution depending on the time delay between the reaction and the drug intake, the tested drug concentration and the chemical drug structure, in both immediate and non-immediate reactions. The importance of cut-off values was assessed in immediate and non-immediate reactions induced by “haptenic” molecules. The discordance between the results of specific IgE to β-lactams and the CD63 expression test on basophils was analysed in β-lactam allergic patients. The subgroup of patients with severe drug-induced reactions was assessed to evaluate the results of CD63 expression tests in clinical practice.

Biographie de l'auteur

Violeta Kvedarienė PhD, MD is consulting allergist at the Vilnius University Hospital, Vilnius, Lithuania. The main topic of the research work is to establish the value of the flow - assisted analysis of in vitro-activated basophils for drug hypersensitivity diagnosis. The research work conducted at the Montpellier University Hospital, France.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
384544004X
ISBN 13 
9783845440040
Reliure
Broché
Nombre de pages
100
Coordonnées du fabricant
non disponible
Personne responsable
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