Biophysical Analysis of an Essential Regulator of the Immune System: Structural analysis of the RFX protein complex, a transcriptional regulator, using NMR methods - Couverture souple

Briggs, LaTese

 
9783845442600: Biophysical Analysis of an Essential Regulator of the Immune System: Structural analysis of the RFX protein complex, a transcriptional regulator, using NMR methods
Couverture souple
ISBN 10 : 3845442603 ISBN 13 : 9783845442600
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

The human adaptive immune system serves as the primary defense against pathogens. While the human adaptive immune response is powered by many components, the Major Histocompatibility Class II (MHCII) molecules lie at the heart of the machinery of the immune system. MHCII display of antigens triggers a cascade of events leading to the immune response. Lack of MHCII expression causes severe immunodeficiency disorders, whereas overproduction of these molecules can cause a variety of autoimmune diseases. The production of MHCII molecules is regulated by a multi-protein complex that includes the Regulatory Factor X (RFX) protein complex, which is comprised of three subunits, RFX5, RFXAP, and RFXB. Mutations or deletions in any RFX subunit that prevents the formation of the MHCII enhanceosome abolishes MHCII expression. A better understanding of how the RFX complex assembles will provide insight into the rational design of novel immunosuppressive therapeutic agents. Our structural analysis of the RFX complex elucidates this complex formation, in efforts to move towards this therapeutic goal.

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Présentation de l'éditeur

The human adaptive immune system serves as the primary defense against pathogens. While the human adaptive immune response is powered by many components, the Major Histocompatibility Class II (MHCII) molecules lie at the heart of the machinery of the immune system. MHCII display of antigens triggers a cascade of events leading to the immune response. Lack of MHCII expression causes severe immunodeficiency disorders, whereas overproduction of these molecules can cause a variety of autoimmune diseases. The production of MHCII molecules is regulated by a multi-protein complex that includes the Regulatory Factor X (RFX) protein complex, which is comprised of three subunits, RFX5, RFXAP, and RFXB. Mutations or deletions in any RFX subunit that prevents the formation of the MHCII enhanceosome abolishes MHCII expression. A better understanding of how the RFX complex assembles will provide insight into the rational design of novel immunosuppressive therapeutic agents. Our structural analysis of the RFX complex elucidates this complex formation, in efforts to move towards this therapeutic goal.

Biographie de l'auteur

Infectious Disease Analyst, Decision Resources Group - presentPostdoctoral Fellow, Chemical Biology, Harvard University/Broad Institute - 2010Ph.D., Structural Biology/ Biochemistry, University of Maryland Baltimore County (UMBC) - 2008 B.A., Chemistry, Hood College - 2002

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3845442603
ISBN 13 
9783845442600
Reliure
Broché
Nombre de pages
124
Coordonnées du fabricant
non disponible
Personne responsable
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