Nephrotoxic Effects of Insecticide Diazinon: Acute, Sub acute and Chronic Studies - Couverture souple

Shah, Muhammad Dawood; Iqbal, Mohammad; J. A. D’Souza, Urban

Couverture souple

ISBN 10 : 3846502375 ISBN 13 : 9783846502372

Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

Diazinon (O,O-diethyl-O-[2-isopropyl-6-methyl-4-pyrimidinyl] phosphoro thioate), an organo-phosphate insecticide, has been used worldwide in agriculture and domestic for several years, which has led to a variety of negative effects in non target species including humans. However, its nephrotoxic effects and mechanism of action has not been fully elucidated so far. Therefore, the present study was aimed at evaluating the nephrotoxic effects of diazinon and its mechanism of action with special reference to its possible ROS generating potential in rats. Treatment of rats with diazinon significantly enhances renal lipid peroxidation which is accompanied by a decrease in the activities of renal antioxidant enzymes (e.g. catalase, glutathione peroxidise, glutathione reductase, glucose-6-phosphate dehydrogenase, glutathione S-transferase) and depletion in the level of glutathione reduced. In contrast, the activities of renal -glutamyl transpeptidase and quinone reductase were increased. Parallel to these changes, diazinon treatment enhances renal damage as evidenced by sharp increase in blood urea nitrogen and serum creatinine.

A propos du livre

À propos de l'auteur

B.Sc (Pakistan), M.Sc (Malaysia), PhD Candidate, University Malaysia Sabah, Malaysia.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2011
• Langue: anglais
• ISBN 10: 3846502375
• ISBN 13: 9783846502372
• Reliure: Broché
• Nombre de pages: 160
• Coordonnées du fabricant: non disponible
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