Development And Evaluation of Carvedilol SR Tablet: Formulation Development - Couverture souple

Halder, Shimul; Shuma, Madhabi Lata; Rouf, Abu Shara Shamsur

 
9783846511251: Development And Evaluation of Carvedilol SR Tablet: Formulation Development
Couverture souple
ISBN 10 : 3846511250 ISBN 13 : 9783846511251
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

Matrix tablets containing carvedilol phosphate were prepared using 27 formulations in three batch series where different ratios of K4M CR and K15M CR were used as release retarding agents. Avicel PH 101, Starch 1500 and Lactose monohydrate were used as diluents in the formulation of three batches. The data were subjected to different models in order to evaluate their release kinetics and mechanisms. Tablets in case of all formulations showed more than 50% of drug release in 12 h when Methocel K4M CR and K15M CR constituted 18% and 15% of the matrix respectively. It was found that Avicel PH 101 decreases while Starch 1500 and Lactose monohydrate increases drug release.

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Présentation de l'éditeur

Matrix tablets containing carvedilol phosphate were prepared using 27 formulations in three batch series where different ratios of K4M CR and K15M CR were used as release retarding agents. Avicel PH 101, Starch 1500 and Lactose monohydrate were used as diluents in the formulation of three batches. The data were subjected to different models in order to evaluate their release kinetics and mechanisms. Tablets in case of all formulations showed more than 50% of drug release in 12 h when Methocel K4M CR and K15M CR constituted 18% and 15% of the matrix respectively. It was found that Avicel PH 101 decreases while Starch 1500 and Lactose monohydrate increases drug release.

Biographie de l'auteur

Shimul Halder,M. Pharm, lecturer, Department of Pharmaceutical Technology,Faculty of Pharmacy,University of Dhaka,Bangladesh.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3846511250
ISBN 13 
9783846511251
Reliure
Broché
Nombre de pages
144
Coordonnées du fabricant
non disponible
Personne responsable
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