Monograph on Genomics of Ageing Gene-Sirt1: Insilico Analysis & Comparative Modelling of Ageing Gene-Sirt1 by Using Bioinformatics Softwares and Tools - Couverture souple

Mahendran, Radha; Muthu, Palani; Sri, Suba

Couverture souple

ISBN 10 : 3846516554 ISBN 13 : 9783846516553

Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

Ageing is a syndrome of changes that are deleterious, progressive, universal & thus irreversible. SIRT1 gene is a candidate gene, involved in ageing process. The SIRT1 gene, whose activity is modified by the body's metabolic state & was previously known to help control the process of ageing and extend the lifespan of humans, also plays a key role in regulating the internal clock. This important discovery helps to explain how the body regulates essential functions such as hormone production, body temperature & blood pressure, & may eventually lead to drugs to combat metabolic disorders, obesity or diabetes. SIRT1 gene codes for the protein ‘SIRTUINS’. By using Bioinformatics Tools & Softwares Exons, Introns, SNPs & RFLPs of SIRT1 were predicted. SNPs are consequently important in understanding human health. Information related to functional SNPs in candidate disease genes is critical for cost effective genetic association studies, which attempt to understand the genetics of complex diseases. The 3D structure of Sirtuin was modeled & Docked with suitable ligands. The SIRT1 activation study helps in medical application for developing SIRT1 activating drugs for ageing problems.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2011
• Langue: anglais
• ISBN 10: 3846516554
• ISBN 13: 9783846516553
• Reliure: Broché
• Nombre de pages: 160
• Coordonnées du fabricant: non disponible
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