HPLC Method Validation Benzofuran Derivatives: Synthesis and HPLC Method validation of Novel 3-Fluoro-N-{[7-methoxy-2-(4-methoxyphenyl-1-benzofuran-5-yl]methyl}aniline - Couverture souple

Thorat, Bapu; Yamgar, Ramesh; More, Kishor

 
9783846519660: HPLC Method Validation Benzofuran Derivatives: Synthesis and HPLC Method validation of Novel 3-Fluoro-N-{[7-methoxy-2-(4-methoxyphenyl-1-benzofuran-5-yl]methyl}aniline
Couverture souple
ISBN 10 : 3846519669 ISBN 13 : 9783846519660
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Number of methods are known for the the synthesis of the natural product 7-Methoxy-2-[4-(methoxy)phenyl)-l-benzofuran-5-carboxaldehyde are known. It is conveniently synthesized by using Intramolecular Wittig reaction of ester. Reductive amination is one of the versatile method for the synthesis of secondary or tertiary amines from aldehydes or ketones by using suitable reducing agent in one-pot fashion. This reaction has been carried out at room temperature and in acidic medium (by using acetic acid). 7-Methoxy-2-[4-(methoxy)phenyl)-l-benzofuran-5-carboxaldehyde was reacted with 3-fluoroaniline in ethylene dichloride in presence of catalytic amount of acetic acid forming 3-fluoro-N-{[7-methoxy-2-(4-methoxyphenyl)-1-benzofuran-5-yl]methyl}aniline. It is novel benzofuran amine. It's HPLC method validation has been carried out and apply to series of compounds.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Number of methods are known for the the synthesis of the natural product 7-Methoxy-2-[4-(methoxy)phenyl)-l-benzofuran-5-carboxaldehyde are known. It is conveniently synthesized by using Intramolecular Wittig reaction of ester. Reductive amination is one of the versatile method for the synthesis of secondary or tertiary amines from aldehydes or ketones by using suitable reducing agent in one-pot fashion. This reaction has been carried out at room temperature and in acidic medium (by using acetic acid). 7-Methoxy-2-[4-(methoxy)phenyl)-l-benzofuran-5-carboxaldehyde was reacted with 3-fluoroaniline in ethylene dichloride in presence of catalytic amount of acetic acid forming 3-fluoro-N-{[7-methoxy-2-(4-methoxyphenyl)-1-benzofuran-5-yl]methyl}aniline. It is novel benzofuran amine. It's HPLC method validation has been carried out and apply to series of compounds.

Biographie de l'auteur

He is Assistant Professor in Chemistry working under Higher Education Department, Government of Maharashtra, Maharashtra State, India. He is In-charge of Post Graduate and Research Center, Department of Chemistry, Ismail Yusuf College, Mumbai, India 400060. He has published 16 International/National Research papers on various topics.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3846519669
ISBN 13 
9783846519660
Reliure
Broché
Nombre de pages
60
Coordonnées du fabricant
non disponible
Personne responsable
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