Corticosteroids And Red Cell System: Cortisol & Erythrocyte - Couverture souple

Agarwal, Kailash

 
9783846523544: Corticosteroids And Red Cell System: Cortisol & Erythrocyte
Couverture souple
ISBN 10 : 3846523542 ISBN 13 : 9783846523544
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

Corticosteroids have been associated with hematological changes i. e. erythropoiesis, neutrophilia, lymphocyte and eosinopenia in endocrinal disorders and hematological diseases i.e. hypoplastic marrow stimulation; immune thrombocytopenia- increase in platelet count and hemoglobin, and in acute lymphoblastic leukemia-remission. The present study conducted in bronchial asthma associated with eosinophilia, in spite of being on long term corticosteroid therapy showed: a) erythropoiesis- about 10% rise in hemoglobin, hematocrit and red cell count. This rise was observed with a dose of hydrocortisone even below 0.49mg/kg per day, with maximum effect on dosages from 0.50-0.99 mg/kg per day and within 3 months of therapy. No further increase was observed with dosages of 1.0-1.99 mg/kg per day. b) On discontinuation of corticosteroid therapy the hemoglobin concentration returned to normal after a period varying from 2 weeks to 4 months. c) The erythropoiesis was further confirmed by demonstrating around 10% increase in total hemoglobin and total red cell volume by Cr51 technique. The blood volume did not change; there was reduction in plasma volume in children receiving corticoste.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Corticosteroids have been associated with hematological changes i. e. erythropoiesis, neutrophilia, lymphocyte and eosinopenia in endocrinal disorders and hematological diseases i.e. hypoplastic marrow stimulation; immune thrombocytopenia- increase in platelet count and hemoglobin, and in acute lymphoblastic leukemia-remission. The present study conducted in bronchial asthma associated with eosinophilia, in spite of being on long term corticosteroid therapy showed: a) erythropoiesis- about 10% rise in hemoglobin, hematocrit and red cell count. This rise was observed with a dose of hydrocortisone even below 0.49mg/kg per day, with maximum effect on dosages from 0.50-0.99 mg/kg per day and within 3 months of therapy. No further increase was observed with dosages of 1.0-1.99 mg/kg per day. b) On discontinuation of corticosteroid therapy the hemoglobin concentration returned to normal after a period varying from 2 weeks to 4 months. c) The erythropoiesis was further confirmed by demonstrating around 10% increase in total hemoglobin and total red cell volume by Cr51 technique. The blood volume did not change; there was reduction in plasma volume in children receiving corticoste.

Biographie de l'auteur

K N Agarwal(MBBS-1959; DCH- 1961 ; MD –Pediatrics 1969) was trained in Pediatric Hematology (M D, Hons 1965) from the University of Uppsala, Sweden. His outstanding contributions are: a) Red cell changes in asthmatic children receiving corticosteroids ; b) Mechanism(s) in red cell lysis-and prevention by corticosteroids.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3846523542
ISBN 13 
9783846523544
Reliure
Broché
Nombre de pages
68
Coordonnées du fabricant
non disponible
Personne responsable
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