Microstructured Interpenetrating Polymer Network Drug Delivery System: Development of Novel Interpenetrating Polymer Network Hydrogel Microspheres For Controlled Release of Diclofenac Sodium - Couverture souple

Banerjee, Subham; Ray, Somasree; Chattopadhyay, Pronobesh

 
9783846524398: Microstructured Interpenetrating Polymer Network Drug Delivery System: Development of Novel Interpenetrating Polymer Network Hydrogel Microspheres For Controlled Release of Diclofenac Sodium
Couverture souple
ISBN 10 : 3846524395 ISBN 13 : 9783846524398
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

Novel interpenetrating network (IPN) hydrogel microspheres, consisting of xanthan gum and poly(vinyl alcohol) were prepared by water-in-oil emulsion crosslinking method using glutaraldehyde for the controlled release of diclofenac sodium,as a model drug.Various formulations were prepared by changing the ratio of XG:PVA, extent of cross-linking in order to optimize the formulation variables on drug encapsulation efciency, and release rate. Formation of IPN and the chemical stability of DS after preparation of microspheres was confrmed by FTIR, DSC & XRD analysis were done which confrmed molecular dispersion of DS in the IPN. Microspheres formed were spherical with smooth surfaces, as evidenced by SEM & mean particle size measured by laser light scattering technique. Drug encapsulation of up to 82.94% was achieved by UV method. Both equilibrium & dynamic swelling studies and in vitro release studies were performed in pH 1.2 and 7.4. Release data indicated Fickian trend of drug release. In vivo pharmacokinetic data showed prolonged drug release as compared with DS solution. Based on the results it was concluded that these IPN microspheres provided controlled release application of DS

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À propos de l'auteur

Mr. Subham Banerjee,M.Pharm from GCTS,West Bengal,India completed his master thesis on novel IPN microspheres under Prof.(Dr.)Somasree Ray. He was a recipient of GATE & DRDO Fellowship. Now, he pursuing his Ph.D from BIT,Ranchi under Dr. P. Chattopadhyay, Sc.-D, DRL & Dr. A. Ghosh, Asst. Prof.(BIT). He published many articles in reputed journals.

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3846524395
ISBN 13 
9783846524398
Reliure
Broché
Nombre de pages
128
Coordonnées du fabricant
non disponible
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