Floating Microspheres: An Intelligent Drug Delivery System: Design and in-vivo evaluation of Floating Microspheres - Couverture souple

Gupta, Rishikesh; Prajapati, S. K.; Pattnaik, Snigdha

 
9783846526415: Floating Microspheres: An Intelligent Drug Delivery System: Design and in-vivo evaluation of Floating Microspheres
Couverture souple
ISBN 10 : 384652641X ISBN 13 : 9783846526415
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

This book initially provides a review of floating drug delivery systems. This system has a bulk density lower than the gastric content. They remain buoyant in the stomach for a prolonged period of time, with the potential for continuous release of drug. Gastric emptying is much more rapid in the fasting state and floating systems really heavily on the presence of food to retard emptying and provide sufficient liquid for effective buoyancy. When microspheres come in contact with gastric fluid the gel formers, polysaccharides, and polymers hydrate to form a colloidal gel barrier that controls the rate of fluid penetration into the device and consequent drug release. The air trapped by the swollen polymer lowers the density and confers buoyancy to the microspheres. However a minimal gastric content needed to allow proper achievement of buoyancy. Hollow microspheres of Acrylic resins 57, Eudragit, PMAA, floating granules are the recent developments in this field. The book then presents studies conducted on producing microspheres containing Antidiabetic drug. The book also discusses various formulation and processing parameters and in-vivo study in wistar rats.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

This book initially provides a review of floating drug delivery systems. This system has a bulk density lower than the gastric content. They remain buoyant in the stomach for a prolonged period of time, with the potential for continuous release of drug. Gastric emptying is much more rapid in the fasting state and floating systems really heavily on the presence of food to retard emptying and provide sufficient liquid for effective buoyancy. When microspheres come in contact with gastric fluid the gel formers, polysaccharides, and polymers hydrate to form a colloidal gel barrier that controls the rate of fluid penetration into the device and consequent drug release. The air trapped by the swollen polymer lowers the density and confers buoyancy to the microspheres. However a minimal gastric content needed to allow proper achievement of buoyancy. Hollow microspheres of Acrylic resins 57, Eudragit, PMAA, floating granules are the recent developments in this field. The book then presents studies conducted on producing microspheres containing Antidiabetic drug. The book also discusses various formulation and processing parameters and in-vivo study in wistar rats.

Biographie de l'auteur

Rishikesh Gupta (Author), M.Pharm (Pharmaceutics), Ph.D. (Siksha O Anushandhan University Bhubaneswar),Odisha,India. Presently He is working as an Asst. Prof. in Institute of Pharmacy, Bundelkhand University, Jhansi (UP) India. He is the Executive Editor of International Journal of Research and Development in Pharmacy and Life Sciences (IJRDPL).

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
384652641X
ISBN 13 
9783846526415
Reliure
Broché
Nombre de pages
100
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne