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Modified alpha-beta Chimeric OligoDNA as a Unique Class of TFO: A Study on Synthesis and Properties of alpha-beta Chimeric OligoDNA - Couverture souple

Azam, A.T.M. Zafrul

 
9783846532461: Modified alpha-beta Chimeric OligoDNA as a Unique Class of TFO: A Study on Synthesis and Properties of alpha-beta Chimeric OligoDNA
Couverture souple
ISBN 10 : 3846532460 ISBN 13 : 9783846532461
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

A series of novel alpha-beta chimeric oligodeoxynucleotides bearing either an intercalator-conjugated nucleobase located at the internal 4-nt linker region or an anthraquinone-conjugated propionic acid as a non-nucleosidic backbone unit at the internal linker region was synthesized. The UV-melting experiments reveled that the obtained modified chimera TFOs formed remarkably stable alternate-stranded triplex. On the other hand, modified TFOs bearing non-nucleosidic intercalator-conjugate possessed two diastereomers formed substantially stable alternate-stranded triple helix almost regardless of the stereochemistry of the incorporated non-nucleosidic backbone unit. The sequence discrimination ability and thermodynamic stability of some TFOs were also examined.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

A series of novel alpha-beta chimeric oligodeoxynucleotides bearing either an intercalator-conjugated nucleobase located at the internal 4-nt linker region or an anthraquinone-conjugated propionic acid as a non-nucleosidic backbone unit at the internal linker region was synthesized. The UV-melting experiments reveled that the obtained modified chimera TFOs formed remarkably stable alternate-stranded triplex. On the other hand, modified TFOs bearing non-nucleosidic intercalator-conjugate possessed two diastereomers formed substantially stable alternate-stranded triple helix almost regardless of the stereochemistry of the incorporated non-nucleosidic backbone unit. The sequence discrimination ability and thermodynamic stability of some TFOs were also examined.

Biographie de l'auteur

Dr. Azam is working as an Assoc. Prof. for Faculty of Pharmacy, University of Dhaka, Bangladesh. His research interest is in Nucleic Acids and Medicinal Chemistry. He obtained his B.Pharm.(Hons.) and M.Pharm. from Univ. of Dhaka, Bangladesh; PhD from Gunma Univ., Japan. He worked as a JSPS Post-Doctoral research Fellow at Kanagawa Univ., Japan.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3846532460
ISBN 13 
9783846532461
Reliure
Broché
Nombre de pages
160
Coordonnées du fabricant
non disponible
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