Articles liés à Development of in situ gel system for ocular drug delivery:...

Development of in situ gel system for ocular drug delivery: Physiologically active mucoadhesive sol to gel system - Couverture souple

Gupta, Himanshu

 
9783846582237: Development of in situ gel system for ocular drug delivery: Physiologically active mucoadhesive sol to gel system
Couverture souple
ISBN 10 : 3846582239 ISBN 13 : 9783846582237
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

In situ gel-forming systems have drawn much attention of current researchers to overcome the poor bioavailability from the conventional eye drops. The present work described formulation and pharmacoscintigraphic evaluation of timolol-maleate-loaded chitosan/hydroxy propyl methyl cellulose(HPMC)-based polymer matrix for enhanced ocular retention. Chitosan and HPMC ratio was optimized and formulation was characterized for various in vitro parameters. The ocular retention was studied on New Zealand rabbits by gamma scintigraphy, which is a very simple and noninvasive technique. For scintigraphy study, the drug timolol maleate was radiolabeled 99mTc by direct labeling method. The labeling procedure was optimized to get maximum labeling efficiency(<98%). Plain drug eliminates rapidly as significant activity was recorded in kidney and bladder after 2 h of ocular administration. It was evident from the scintigraphic images and the time–activity curve plotted from the data that the plain drug solution cleared very rapidly than developed in situ gel formulation.Developed formulation cleared at a slow rate and remained at corneal surface for longer time duration proving its efficacy.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

In situ gel-forming systems have drawn much attention of current researchers to overcome the poor bioavailability from the conventional eye drops. The present work described formulation and pharmacoscintigraphic evaluation of timolol-maleate-loaded chitosan/hydroxy propyl methyl cellulose(HPMC)-based polymer matrix for enhanced ocular retention. Chitosan and HPMC ratio was optimized and formulation was characterized for various in vitro parameters. The ocular retention was studied on New Zealand rabbits by gamma scintigraphy, which is a very simple and noninvasive technique. For scintigraphy study, the drug timolol maleate was radiolabeled 99mTc by direct labeling method. The labeling procedure was optimized to get maximum labeling efficiency(<98%). Plain drug eliminates rapidly as significant activity was recorded in kidney and bladder after 2 h of ocular administration. It was evident from the scintigraphic images and the time–activity curve plotted from the data that the plain drug solution cleared very rapidly than developed in situ gel formulation.Developed formulation cleared at a slow rate and remained at corneal surface for longer time duration proving its efficacy.

Biographie de l'auteur

Himanshu Gupta had completed his D.Pharm, B.Pharm, M.Pharm, PGDIB, PhD, Post Doc (USA). He is working on ocular drug delivery systems, biomaterials, nuclear medicines and gamma scintigraphic techniques. He published his work in journals of repute and involved with many socities i.e. Organization of Pharmaceutical Unity with BioAllied Sciences etc.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3846582239
ISBN 13 
9783846582237
Reliure
Broché
Nombre de pages
128
Coordonnées du fabricant
non disponible
Personne responsable
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