Bioinformatic Approaches to Structure and Function of Protein: Structural and Functional Analysis of Rhodopsin - Couverture souple

Kanwal, Shagufta; NIshat, Sumaira; Khan, Muhammad Irfan

 
9783846584361: Bioinformatic Approaches to Structure and Function of Protein: Structural and Functional Analysis of Rhodopsin
Couverture souple
ISBN 10 : 3846584363 ISBN 13 : 9783846584361
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

This book provides a compact knowledge about practical applications of bioinformatic approaches to understand the structure and function of a protein- Rhodesian which is found in visual pigment of eye and responsible for controlling night vision. Its structure has been predicted by comparative homology modelling and model evaluation through various tools. The electron density maps of retinal isomers and structure of rhodopsin intermediates were analyzed by structure superimposition. On the basis of structural analysis of thirteen mutations for Autosomal Dominant Retinitis Pigmentosa, one of the missense mutation has been targeted to propose a drug to cure night blindness. The molecular docking technique has also been used to predict ligand interactions with rhodopsin. It is hoped that this will provide new insights into structural and functional exploration of proteins which will be helpful in understanding various vital phenomena like protein activation and inhibition, drug interactions and protein signaling.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

This book provides a compact knowledge about practical applications of bioinformatic approaches to understand the structure and function of a protein- Rhodesian which is found in visual pigment of eye and responsible for controlling night vision. Its structure has been predicted by comparative homology modelling and model evaluation through various tools. The electron density maps of retinal isomers and structure of rhodopsin intermediates were analyzed by structure superimposition. On the basis of structural analysis of thirteen mutations for Autosomal Dominant Retinitis Pigmentosa, one of the missense mutation has been targeted to propose a drug to cure night blindness. The molecular docking technique has also been used to predict ligand interactions with rhodopsin. It is hoped that this will provide new insights into structural and functional exploration of proteins which will be helpful in understanding various vital phenomena like protein activation and inhibition, drug interactions and protein signaling.

Biographie de l'auteur

Shagufta Kanwal is presently lecturer of Bioinformatics and Biotechnology at International Islamic University Islamabad, Pakistan. She has research publications on major domains of bioinformatics in accompany of her coleague Sumaira Nishat,presently bioinformatics lecturer, under the infallible motivation and guidance of Prof. Muhammad Irfan Khan.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3846584363
ISBN 13 
9783846584361
Reliure
Broché
Nombre de pages
128
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne