QSAR Based Design & Synthesis: Design, Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives - Couverture souple

Jain, Priyal; Jain, Nilesh; Jain, Vaibhav

9783846586020: QSAR Based Design & Synthesis: Design, Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives

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ISBN 10 : 3846586021 ISBN 13 : 9783846586020

Editeur : LAP LAMBERT Academic Publishing, 2012

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We carried out a QSAR study on benzotriazine derivatives & studied 28 potent GABAA receptor ligands; derivatives of benzotriazines, using a combination of various physicochemical, steric, electronic and thermodynamic descriptors to determine the quantitative correlation between binding affinity and structural features with potent anticonvulsant activity. Correlation between these properties and anticonvulsant activity was used to synthesize compounds possessing potent anticonvulsant activity. Most of the compounds showed an ability to inhibit the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions. Compound 1A, i.e. 2-(4-Chloro-phenyl)-5-nitro-1H-benzimidazole exhibited maximum activity.

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�diteurLAP LAMBERT Academic Publishing
Date d'�dition2012
ISBN 10 3846586021
ISBN 13 9783846586020
ReliureBroch�
Langueanglais
Nombre de pages76
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QSAR Based Design & Synthesis

Priyal Jain|Nilesh Jain|Vaibhav Jain

Edit� par LAP LAMBERT Academic Publishing, 2012

ISBN 10 : 3846586021 ISBN 13 : 9783846586020

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Jain PriyalPriyal Jain Asst. Prof Sagar Institute of Research and Technology-Pharmacy, Bypass Road, Bhopal-462036 (M.P), India. He has devoted their work to develop different 3D & 2D QSAR models for drug design.We carried out a Q. N� de r�f. du vendeur 5501408

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QSAR Based Design & Synthesis : Design, Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives

Priyal Jain

Edit� par LAP LAMBERT Academic Publishing, 2012

ISBN 10 : 3846586021 ISBN 13 : 9783846586020

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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - We carried out a QSAR study on benzotriazine derivatives & studied 28 potent GABAA receptor ligands; derivatives of benzotriazines, using a combination of various physicochemical, steric, electronic and thermodynamic descriptors to determine the quantitative correlation between binding affinity and structural features with potent anticonvulsant activity. Correlation between these properties and anticonvulsant activity was used to synthesize compounds possessing potent anticonvulsant activity. Most of the compounds showed an ability to inhibit the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions. Compound 1A, i.e. 2-(4-Chloro-phenyl)-5-nitro-1H-benzimidazole exhibited maximum activity. N� de r�f. du vendeur 9783846586020

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QSAR Based Design & Synthesis

Priyal Jain

Edit� par LAP LAMBERT Academic Publishing Feb 2012, 2012

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -We carried out a QSAR study on benzotriazine derivatives & studied 28 potent GABAA receptor ligands; derivatives of benzotriazines, using a combination of various physicochemical, steric, electronic and thermodynamic descriptors to determine the quantitative correlation between binding affinity and structural features with potent anticonvulsant activity. Correlation between these properties and anticonvulsant activity was used to synthesize compounds possessing potent anticonvulsant activity. Most of the compounds showed an ability to inhibit the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions. Compound 1A, i.e. 2-(4-Chloro-phenyl)-5-nitro-1H-benzimidazole exhibited maximum activity. 76 pp. Englisch. N� de r�f. du vendeur 9783846586020

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QSAR Based Design & Synthesis

Priyal Jain

Edit� par LAP LAMBERT Academic Publishing Feb 2012, 2012

ISBN 10 : 3846586021 ISBN 13 : 9783846586020

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Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne

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Taschenbuch. Etat : Neu. Neuware -We carried out a QSAR study on benzotriazine derivatives & studied 28 potent GABAA receptor ligands; derivatives of benzotriazines, using a combination of various physicochemical, steric, electronic and thermodynamic descriptors to determine the quantitative correlation between binding affinity and structural features with potent anticonvulsant activity. Correlation between these properties and anticonvulsant activity was used to synthesize compounds possessing potent anticonvulsant activity. Most of the compounds showed an ability to inhibit the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions. Compound 1A, i.e. 2-(4-Chloro-phenyl)-5-nitro-1H-benzimidazole exhibited maximum activity.Books on Demand GmbH, �berseering 33, 22297 Hamburg 76 pp. Englisch. N� de r�f. du vendeur 9783846586020

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