Pancratistatin: An Apoptosis Inducer: Applications to Cancer Therapy - Couverture souple

Prajapati, Rajesh N.; Raval, Bhuvan P.; Patel, Rajesh M.

 
9783846597262: Pancratistatin: An Apoptosis Inducer: Applications to Cancer Therapy
Couverture souple
ISBN 10 : 3846597260 ISBN 13 : 9783846597262
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

Abnormalities during the life span of cell lead to serious fault and hence cell cannot function well and hence due to apoptosis the cell get suicide without harming the neighbor cell. Apoptosis is strictly regulated by cell machinery using Fas, Caspases, Death receptor and TNF receptors. Pancratistatin, alkaloids from the amaryllidaceae family induce the apoptosis in cancer cell by different mechanism like upregulation of Fas, increase in caspase-3, destabilization of mitochondrial membrane potential and flipping of phosphatidyl serine. Pancratistatin promises to induce the apoptosis in the cancer cells and produce lesser cytotoxic effect on the normal cells. This natural product can reveal and unveil the horizon for the new-targeted therapy, which is more effective and promising. Due to lesser yield of pancratistatin from the plant source, chemical synthesis by chemoenzymatic process is beneficiary to us for making library for the pancratistatin and its derivatives.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Abnormalities during the life span of cell lead to serious fault and hence cell cannot function well and hence due to apoptosis the cell get suicide without harming the neighbor cell. Apoptosis is strictly regulated by cell machinery using Fas, Caspases, Death receptor and TNF receptors. Pancratistatin, alkaloids from the amaryllidaceae family induce the apoptosis in cancer cell by different mechanism like upregulation of Fas, increase in caspase-3, destabilization of mitochondrial membrane potential and flipping of phosphatidyl serine. Pancratistatin promises to induce the apoptosis in the cancer cells and produce lesser cytotoxic effect on the normal cells. This natural product can reveal and unveil the horizon for the new-targeted therapy, which is more effective and promising. Due to lesser yield of pancratistatin from the plant source, chemical synthesis by chemoenzymatic process is beneficiary to us for making library for the pancratistatin and its derivatives.

Biographie de l'auteur

Rajesh N. Prajapati, M. Pharm is interested in cancer genomics research.Bhuvan P. Raval, M. Pharm, PGDPRA, MBA,(Ph. D.), FSAB is an Assistant Professor at K. J. College of Pharmacy, Vadasma.Rajesh M. Patel, M.Pharm, Ph. D. is an Assistant Professor at S. K. Patel College of Pharma. Edu. & Research.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3846597260
ISBN 13 
9783846597262
Reliure
Broché
Nombre de pages
56
Coordonnées du fabricant
non disponible
Personne responsable
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