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Method Development of Acarbose As API and Tablet Dosage Form.: Method Development of Acarbose as API & Tablet Dosage Form By UV-Vis Spectrophotometer - Couverture souple

Kumar, Ganesh

 
9783846599655: Method Development of Acarbose As API and Tablet Dosage Form.: Method Development of Acarbose as API & Tablet Dosage Form By UV-Vis Spectrophotometer
Couverture souple
ISBN 10 : 3846599654 ISBN 13 : 9783846599655
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

A simple rapid spectrophotometeric method has been developed for estimation of acarbose from bulk drug and tablet dosage form by using potassium permagnate and sodium hydroxide as oxidizing agent. The method is based on the formation of green colored complex of drug with 0.1 N alkaline potassium permanganate having absorbance maxima at 625 nm. The beer’s law is obeyed in the concentration range of 10-70 µg/ml of the drug but more precisely it obeys in the range of 10-50 µg/ml. The slope and intercept values are 0.0118 and 0.0071, respectively. Results of analysis of this method were validated statistically and by recovery studies. The method is applied to the marketed tablet formulation. Result of analysis of tablet formation given as percentage of label claim+ standard deviation is 99.78 + 0.1053. The precision and accuracy was examined by performing recovery studies and was found to be 99.59 + 0.180.The developed method is simple, sensitive and reproducible and can be used for routine analysis of acarbose from bulk and tablet dosage form.

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Présentation de l'éditeur

A simple rapid spectrophotometeric method has been developed for estimation of acarbose from bulk drug and tablet dosage form by using potassium permagnate and sodium hydroxide as oxidizing agent. The method is based on the formation of green colored complex of drug with 0.1 N alkaline potassium permanganate having absorbance maxima at 625 nm. The beer’s law is obeyed in the concentration range of 10-70 µg/ml of the drug but more precisely it obeys in the range of 10-50 µg/ml. The slope and intercept values are 0.0118 and 0.0071, respectively. Results of analysis of this method were validated statistically and by recovery studies. The method is applied to the marketed tablet formulation. Result of analysis of tablet formation given as percentage of label claim+ standard deviation is 99.78 + 0.1053. The precision and accuracy was examined by performing recovery studies and was found to be 99.59 + 0.180.The developed method is simple, sensitive and reproducible and can be used for routine analysis of acarbose from bulk and tablet dosage form.

Biographie de l'auteur

Dr. Ganesh Kumar Bhatt, Assistant Professor, Division of Pharmaceutical Sciences, Shri Guru Ram Rai Institute of Technology & Science, Dehradun, Uttarakhand,INDIA. published 13 research papers in various international & national scientific journals and presented number of research papers in national conferences.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3846599654
ISBN 13 
9783846599655
Reliure
Broché
Nombre de pages
56
Coordonnées du fabricant
non disponible
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