C. elegans and Innate Immunity: A proteomic approach - Couverture souple

Ponnuraj, Srinivasan; Manickam, Raja Lakshmi

Couverture souple

ISBN 10 : 3847300466 ISBN 13 : 9783847300465

Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

The striking similarities between the innate defenses of vertebrates and invertebrates as well as the amenability of Caenorhabditis elegans for genetic analysis have made this free-living ground nematode a popular model system in the study of bacterial pathogenesis. Although genetic studies have brought new insights, showing the inducibility and pathogen-specificity of the immune response, there is still much to be discovered about the exact mechanisms underlying resistance to infection. In this study a different angle was adopted to study host–pathogen interactions in C. elegans. Given the dynamic nature of an immune response, the proteome of C. elegans was investigated at four different time-points (24, 48, 72, 96 h) after infection with S. typhi, S. typhi Ty21a, C. sakazakii and E. coli OP50 using SDS PAGE as a preliminary step to detect variation in the whole protein content.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2012
• Langue: anglais
• ISBN 10: 3847300466
• ISBN 13: 9783847300465
• Reliure: Broché
• Nombre de pages: 100
• Coordonnées du fabricant: non disponible
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