Articles liés à Identification & analysis of suitable drug like...

Identification & analysis of suitable drug like compound for NDM-1: A Computational Approach - Couverture souple

Patel, Ashish; Choubey, Jyotsna; Verma, M. K.

 
9783847300946: Identification & analysis of suitable drug like compound for NDM-1: A Computational Approach
Couverture souple
ISBN 10 : 3847300946 ISBN 13 : 9783847300946
Editeur : LAP LAMBERT Academic Publishing, 2011

Synopsis

It has been reported that many tested and established antibiotics does not perform well in general and sometimes it is totally ineffective in specific cases. This inactiveness is inhibited by presence of some unwanted proteins received from different origins. In the present book one of such enzymes named NDM-1, its behavior and hindrance characteristics in the working of certain group of antibiotics wiz. A Carbapenem antibiotic has been addressed thoroughly. The mechanism of hindrance to particular group of drugs especially Polymyxins and Tigecycline antibiotics has been very frequently observed. To alleviate this undesirable situation docking of possible drug compounds with diseased proteins has been exhibited. Further, out of possible drug compounds best drug compound is identified after docking exercise of drugs over NDM-1. The best performing drug has been identified as CID 6249, Stock1n-13321 and CID 2174. The sole purpose of writing this book is to encourage similar researches. So as the solution of ineffectiveness of established, very important and life saving antibiotics may be obtained by and large in wide spectrum.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

It has been reported that many tested and established antibiotics does not perform well in general and sometimes it is totally ineffective in specific cases. This inactiveness is inhibited by presence of some unwanted proteins received from different origins. In the present book one of such enzymes named NDM-1, its behavior and hindrance characteristics in the working of certain group of antibiotics wiz. A Carbapenem antibiotic has been addressed thoroughly. The mechanism of hindrance to particular group of drugs especially Polymyxins and Tigecycline antibiotics has been very frequently observed. To alleviate this undesirable situation docking of possible drug compounds with diseased proteins has been exhibited. Further, out of possible drug compounds best drug compound is identified after docking exercise of drugs over NDM-1. The best performing drug has been identified as CID 6249, Stock1n-13321 and CID 2174. The sole purpose of writing this book is to encourage similar researches. So as the solution of ineffectiveness of established, very important and life saving antibiotics may be obtained by and large in wide spectrum.

Biographie de l'auteur

M. Sc.: V. B. S. Purvanchal University Jaunpur (U.P.), M. Phil.: Global Open University Nagaland, APGD: CSJM University Kanpur (U.P.), India. Information Officer (R & D) at Sub-DIC Bioinformatics, National Institute of Technology Raipur (Institute of National Importance), (C.G) India.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3847300946
ISBN 13 
9783847300946
Reliure
Broché
Nombre de pages
68
Coordonnées du fabricant
non disponible
Personne responsable
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