Molecular Characterization of Optochin Resistant Strep pneumoniae: Phenotypic and genotypic Characterization of Optochin Resistant Streptococcus Pneumoniae - Couverture souple

Nasrin, Nishat; Asaduzzaman, Muhammad; Chowdhury, A.K. Azad

 
9783847308829: Molecular Characterization of Optochin Resistant Strep pneumoniae: Phenotypic and genotypic Characterization of Optochin Resistant Streptococcus Pneumoniae
Couverture souple
ISBN 10 : 3847308823 ISBN 13 : 9783847308829
Editeur : LAP LAMBERT Academic Publishing, 2011

Présentation de l'éditeur

Out of 1500 nasopharyngeal swab samples collected from patients who were admitted to different maternity clinics in Dhaka city, 111 optochin resistant strains were isolated. As a confirmatory test of Streptococcus pneumoniae, i.e., Bile solubility was checked. A total of 37 optochin resistant bile soluble isolates were obtained, designated as optochin resistant bile soluble S. pneumoniae as other - hemolytic streptococci are not bile soluble. For further identification, bile soluble isolates were subjected to PCR of the lytA gene specific for S. pneumonia an 32 (87%) isolates were found to be lytA positive. Thus, it can be suggested that for confirmatory identification of S. pneumoniae, bile solubility test together with PCR of lytA gene should be carried out in routine microbilogical investigation. Antimicrobial susceptibility test revealed multiple drug resistance among the organisms. About 64.86% were resistant to more than three agents (multi drug resistant). Higher MIC values were obtained for azithromycin (≤256 microg/ml), erythromycin (≤256 microg/ml) and ciprofloxacin (≤8 microg/ml) considering the CLSI break point.

Biographie de l'auteur

Nishat Nasrin is a Senior Lecturer, Dept. of Pharmacy, East West University, Dhaka, Bangladesh.Muhammad Asaduzzaman is a Lecturer, Dept. of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka, Bangladesh.Dr. A.K. Azad Chowdhury is a Professor, Dept. of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka, Bangladesh.

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Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2011
Langue
anglais
ISBN 10 
3847308823
ISBN 13 
9783847308829
Reliure
Broché
Nombre de pages
100
Coordonnées du fabricant
non disponible
Personne responsable
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