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Enzyme Mimic to Develop Antioxidant Nanoreactors: From Synthesis to Application - Couverture souple

Balasubramanian, Vimalkumar

 
9783847331216: Enzyme Mimic to Develop Antioxidant Nanoreactors: From Synthesis to Application

Synopsis

Reactive oxygen species have been implicated in various diseases, but attempts to find efficient antioxidant treatments for such conditions have met with only limited success. This work describes an antioxidant nanoreactor obtained by encapsulating a dual-enzyme mimic in polymeric nanovesicles. As the mimic detoxifies in situ both superoxide radicals and related hydrogen peroxide, the nanoreactor exhibits antioxidant activity in THP-1 cells. Development of this simple, robust antioxidant nanoreactor represents a new direction in efficiently fighting oxidative stress.

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Présentation de l'éditeur

Reactive oxygen species have been implicated in various diseases, but attempts to find efficient antioxidant treatments for such conditions have met with only limited success. This work describes an antioxidant nanoreactor obtained by encapsulating a dual-enzyme mimic in polymeric nanovesicles. As the mimic detoxifies in situ both superoxide radicals and related hydrogen peroxide, the nanoreactor exhibits antioxidant activity in THP-1 cells. Development of this simple, robust antioxidant nanoreactor represents a new direction in efficiently fighting oxidative stress.

Biographie de l'auteur

Dr. Vimalkumar Balasubramanian graduated in Microbiology as well as in Nanotechnology and received his PhD degree in Chemistry. His research interests are focused on pharmaceutical nanotechnology for the development of nano-carrier systems.

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