Molecular Determinants of Glioma Risk and Patient Prognosis - Couverture souple

Costa, Bruno M.; Magalhães, Ana Xavier

 
9783847335023: Molecular Determinants of Glioma Risk and Patient Prognosis
Couverture souple
ISBN 10 : 3847335022 ISBN 13 : 9783847335023
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Gliomas encompass a wide variety of particularly devastating tumors, for which efficient therapies are not available. Their etiology remains mostly undetermined: so far, only exposure to high‐dose therapeutic radiation has been firmly established as a risk factor, but other plausible causes include genetic syndromes, familial aggregation, and genetic polymorphisms. The clinical performance status and patient age at diagnosis are definite features associated with outcome, but recent evidences suggest that tumor’s molecular traits are also major determinants of prognosis. This book aims to review and discuss how molecular determinants may affect glioma risk and patient outcome, with a very special emphasis in glioblastoma multiforme, the most common and malignant glioma subtype. To do so, Part I presents a general introduction that summarizes the classification, epidemiology, and treatment of gliomas, while devoting particular attention to potential etiological factors and molecular alterations of these tumors. Part II presents original research studies emphasizing the relevance of particular biomarkers of glioma, particularly at the levels of glioma risk and patient prognosis.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Gliomas encompass a wide variety of particularly devastating tumors, for which efficient therapies are not available. Their etiology remains mostly undetermined: so far, only exposure to high-dose therapeutic radiation has been firmly established as a risk factor, but other plausible causes include genetic syndromes, familial aggregation, and genetic polymorphisms. The clinical performance status and patient age at diagnosis are definite features associated with outcome, but recent evidences suggest that tumor’s molecular traits are also major determinants of prognosis. This book aims to review and discuss how molecular determinants may affect glioma risk and patient outcome, with a very special emphasis in glioblastoma multiforme, the most common and malignant glioma subtype. To do so, Part I presents a general introduction that summarizes the classification, epidemiology, and treatment of gliomas, while devoting particular attention to potential etiological factors and molecular alterations of these tumors. Part II presents original research studies emphasizing the relevance of particular biomarkers of glioma, particularly at the levels of glioma risk and patient prognosis.

Biographie de l'auteur

Dr. Bruno M. Costa has obtained his PhD degree in Biological and Biomedical Sciences in 2008. During his scientific career he has worked in several research groups in Portugal, Netherlands, and USA. He is the author of several articles published in prestigious peer-reviewed journals, and has received more than 10 academic and scientific awards.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3847335022
ISBN 13 
9783847335023
Reliure
Broché
Nombre de pages
188
Coordonnées du fabricant
non disponible
Personne responsable
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